DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and bi

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	746	Identity:	195/746 - (26%)
Similarity:	282/746 - (37%)	Gaps:	170/746 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSGNVSGGGGGGGAGGGAGSGSPQHVTHNG-HGHGHGLGGVAAVSGGGASVSGNGGHRVVGGAGS 79
            |:|:.:|...|...|||.  ..|.|  |.| |.|.|.||.....:           ..||..:..
  Fly   254 LAGSPAGPHPGLYPGGGL--RFPPH--HPGAHPHAHHLGSAYTTA-----------EDVVLASAV 303

  Fly    80 PNELDRNLR-----------------ISLDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGL 127
            .::|...:|                 ::|:.::||.:|..|..||::||:||:|||.:|...|||
  Fly   304 AHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGL 368

  Fly   128 DPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNPIYVHPESPNFGAHWMKEPISFAKVK 192
            |..|.|.:||:.|..|.:|:|:.|..|:..|||:......:|:||:||..|..||::.:||.|:|
  Fly   369 DAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLK 433

  Fly   193 LTNK-TNGNGQI---MLNSLHKYEPRVHLVRVG-------SEQRHVVTYPFPETQFIAVTAYQNE 246
            |||. ::.:|.:   :|||:|||:||.||||..       |..|   ||.|.||:||||||||||
  Fly   434 LTNNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFR---TYVFKETEFIAVTAYQNE 495

  Fly   247 EVTSLKIKYNPFAKAFLDA----KER-----------PDTLYP----------HDTHYGWLIPPP 286
            ::|.|||..|||||.|.|.    :|:           .|.|.|          |..|.|  .||.
  Fly   496 KITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAG--RPPH 558

  Fly   287 THYTAA-----------AAAVAAPP-----PL--SIAQSHGLVASCPSVSSAESVGPSSGGSCDR 333
            .|..||           ...|..||     ||  |:.|.|....|....:....:..:..|:.:.
  Fly   559 LHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEH 623

  Fly   334 YGRSLSSRSVAPTRTTPYSRPRVVSGSGSNGSAGNASSTSPQPPSAPQTPTSLHSTSTGSVSTSV 398
            ...:.::.|..............|...||:.|...:...|        |..:...|||||...:|
  Fly   624 AAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGS--------TGGAFRPTSTGSPKEAV 680

  Fly   399 -SSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTASVFSYPSSWQSNGNY--------WNATSV 454
             ::::....|..|..|.:.|.....| ..:..||....:.||     :|.|        .|..:.
  Fly   681 GAAAAAAAAGLNPGGGSYPSPNISVG-PPIHPSPHLLPYLYP-----HGLYPPPHLGLLHNPAAA 739

  Fly   455 PGPMPMNVCSGRNISS--------------------HNSPSPTNG------SPSYTTSSPSYTIH 493
            ....|..:..|...::                    |...||..|      ||.....|......
  Fly   740 AAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLGSAFD 804

  Fly   494 HLTPHSHQYNMAQTDIYGTGVGVGGGAGTTGSPQAAYGAAAHQVYHPTPTSPTHQLYTNAVLNAP 558
            .:||.|:. |.:.....|.|.|:|||....|....:.........|..||.|.....|    ..|
  Fly   805 AVTPGSNA-NRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPISMSPT----TPP 864

  Fly   559 SALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIPLEIGYATHPLEPVDVSKTLDDPQAAMYKPS 623
            |.:.....|             .|.|...|.::.|.|:......:..::|........||
  Fly   865 SLMKQPRGG-------------GAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAAA----- 911

  Fly   624 DEQGSVITLECASSSLKSSHDIKIESSSLEH 654
                  ..|:.|..:.:..|..:......:|
  Fly   912 ------AALQLAEEAAQHHHHTQAHHQQQQH 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	89/213 (42%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	18/72 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	87/185 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910