DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and Tbx21

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001100513.1	Gene:	Tbx21 / 303496	RGDID:	1308264	Length:	528	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	171/570 - (30%)
Similarity:	232/570 - (40%)	Gaps:	158/570 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DPTTGLSGNVSGGGGGGGA----------GGGAGSGSPQHVTHNGHGH----------GHGLGGV 55
            |..||.....|..|.|.||          .|.......:.|:..|..:          |..||..
  Rat    10 DMLTGTEPIPSDEGRGTGADQQHRFFYPESGAQDPTDRRAVSSLGSSYSGSALVPAPPGRFLGAY 74

  Fly    56 A--------AVSGGGASV---SGNGGHRVVGGAGSPN-------------------ELDRNLRIS 90
            |        ...|.|.|.   :|..|:..|.|..:|:                   |:...||::
  Rat    75 AYPPRAQATGFPGPGESFPPPAGAEGYPPVDGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVA 139

  Fly    91 LDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWV 155
            |.:..||.:|.....|||:||.||||||.:..:.:||:|.:.|.:.::.|.:|.|.|:|.:|:||
  Rat   140 LSNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWV 204

  Fly   156 PGGKAE-VPPSNPIYVHPESPNFGAHWMKEPISFAKVKLTN----KTNGNGQIMLNSLHKYEPRV 215
            ..|||| ..|.|.:||||:|||.|||||::.:||.|:||||    ..|....|:|.|||||:||:
  Rat   205 QCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRL 269

  Fly   216 HLVRVG--------SEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKERPDTL 272
            |:|.|.        |...|:.|  |.||||||||||||.|:|.|||..|||||.|.:..|
  Rat   270 HIVEVNDGEPEAACSANTHIFT--FQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFE----- 327

  Fly   273 YPHDTHYGWLIPPPTHYTAAAAAVAAPP-------------PLSIAQ---SHGLVASCPS----- 316
                          :.||:...:|.:||             ||...|   |.......|.
  Rat   328 --------------SMYTSVDTSVPSPPGPNCQLLGGDPYSPLLSNQYPVSSRFYPDLPGQPKDM 378

  Fly   317 VSSAESVGPSSGGSCDRYGRSLSSRSV----APTRTTPYSR-PRVVS-GSGSNGSAGNASSTSPQ 375
            ||.:..:|.....|.:...|::|.:..    ||..|.||.| |.|:: |:|.
  Rat   379 VSQSYWLGTPREPSYETEFRAVSVKPTFLPSAPGTTVPYYRGPDVLAPGAGW------------- 430

  Fly   376 PPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTASVFSYPS 440
             |.|||.|..:  :..|...|..:.....|:||:...|.                        ||
  Rat   431 -PMAPQYPPKM--SPAGWFRTMRTLPMDPGLGSSEEQGS------------------------PS 468

  Fly   441 SWQSNGNYWNATSV-PGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSPS 489
            .|.      ..||: |.|....:..|.......||.|::|..|....:||
  Rat   469 LWT------EVTSLQPEPSDSGLGEGDTKRRRISPYPSSGDSSSPAGAPS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	94/194 (48%)
Tbx21	NP_001100513.1	T-box	138..324	CDD:279278	92/187 (49%)
Tbx21	NP_001100513.1	T-box_assoc	<392..518	CDD:292794	39/167 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810