DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and tbx4

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_570989.2	Gene:	tbx4 / 30070	ZFINID:	ZDB-GENE-991124-5	Length:	543	Species:	Danio rerio

Alignment Length:	570	Identity:	172/570 - (30%)
Similarity:	260/570 - (45%)	Gaps:	122/570 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GGVAAVSGGGASVSGNGGHRVVGGAGSP-----NELDR---NLRISLDDRELWLRFQNLTNEMIV 109
            |...|.|||...::.:..|  :|...:|     ||.|:   |:::.|.|||||.:|.....|||:
Zfish    13 GMTVAQSGGRPELASDSSH--LGLPTTPSNPQNNEPDQSIENIKVVLHDRELWKKFHEAGTEMII 75

  Fly   110 TKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNPIYVHPES 174
            ||.||||||..|:..:|::|...|.:|.:.|..|.||:|:.:.:|:..||||......:||||:|
Zfish    76 TKAGRRMFPSYKVKVTGMNPKTKYILLTDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDS 140

  Fly   175 PNFGAHWMKEPISFAKVKLTNK-TNGNGQIMLNSLHKYEPRVHLVRV------GSEQRHVVTYPF 232
            |..|||||::.:||.|:||||. .:..|.|:|||:|||:||:|:|:.      ||:.....|:.|
Zfish   141 PATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAYCTHVF 205

  Fly   233 PETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKE---RPDTLYPHDTHYGWLIPPPTHYTAAAA 294
            .||.||:||:|||.::|.|||:.|||||.|..:.|   |...|...|      .|..:.......
Zfish   206 HETAFISVTSYQNHKITQLKIENNPFAKGFRGSDEGDLRVSRLQGKD------YPVISKNMVRQR 264

  Fly   295 AVAAPPPLSIAQSHGLVASCPSVSS----AESVGPSSGGSCDRYGRSLSSRSVAPT--------R 347
            .:::...||...|.|:::|.|.|.|    ...|...:..|.:....|.:| |..|:        |
Zfish   265 LISSHGHLSGKLSAGVLSSHPQVLSHYQYDSGVPLPNSDSQEALSNSFTS-SREPSLLYHCFKHR 328

  Fly   348 TTP------YSRPRVVSGSGSNGSAGNASSTSPQPPSAPQTPTSLH---STSTGS----VSTSVS 399
            ..|      ..||.:    .:..||.:.......|||. .:|...|   :.:.||    :...:.
Zfish   329 DNPRHLELGCKRPYL----DTTSSAVSEEHYFRSPPSY-DSPLLSHPYCNEALGSREACMYGGLE 388

  Fly   400 SSSGGGIGS----APSTGC--FSS--SYAQSGFMSVDASPTASVFSYPSSWQSNGNYWNATSVPG 456
            ...||.:|:    |||..|  ::|  .|.:.|..:|:|          ..:|....::|:|:
Zfish   389 GEGGGAVGTDDLPAPSLNCNMWASVQPYPRYGMQTVEA----------MQYQPFTAHFNSTA--- 440

  Fly   457 PMPMNVCSGRNISSHNSPS-----PT-------------NGSPSYTTSSPSYTIHHLTPHSHQYN 503
                   |..::.||:|||     ||             ..:||..::|||.:.||...||..::
Zfish   441 -------SAASMVSHHSPSMQRPHPTPPDLVTFTTQRVLPPTPSSASTSPSGSGHHDRAHSSLFH 498

  Fly   504 MAQTDIYGTGVGVGGGAGTTGSP-QAAYGAAAHQVYHPTPT-SPTHQLYT 551
            .                 ..||| ::......:..:.|||| .|.:|..|
Zfish   499 R-----------------KAGSPLRSQRDFTGYSTHSPTPTREPAYQYQT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	88/191 (46%)
tbx4	NP_570989.2	TBOX	52..240	CDD:238106	87/187 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810