DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment byn and Tbx15

DIOPT Version :9

Sequence 1:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_033349.2	Gene:	Tbx15 / 21384	MGIID:	1277234	Length:	602	Species:	Mus musculus

Alignment Length:	507	Identity:	152/507 - (29%)
Similarity:	236/507 - (46%)	Gaps:	92/507 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VVGGAGSP-----NELDRNLRISLDDRELWLRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAM 132
            :..||..|     :.:: .:::.|...:||.||.::..|||:||.||||||.:::..:||||...
Mouse    95 LASGAAGPVPAAMSSME-EIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQ 158

  Fly   133 YTVLLEFVQIDSHRWKYV--NGEWVPGGKAEVPPSNPIYVHPESPNFGAHWMKEPISFAKVKLT- 194
            |.:.::.|.:|:.|::||  :.:|:..|.|:.|....:|:||:|...|..||::.:||.|:|||
Mouse   159 YYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTN 223

  Fly   195 NKTNGNGQIMLNSLHKYEPRVHLVR--------------VGSEQRHVVTYPFPETQFIAVTAYQN 245
            |:.:..|.|:|:|:|||:||||::|              ||.   .|.|:.||||.|..||||||
Mouse   224 NELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGD---GVKTFNFPETVFTTVTAYQN 285

  Fly   246 EEVTSLKIKYNPFAKAFLDAKERPDTLYPHDTHYGWLIPP------------------PTHYTAA 292
            :::|.|||..|||||.|.|:......|......|.:..||                  .|..:..
Mouse   286 QQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPT 350

  Fly   293 AAAVAAPPPLSIAQSHGLVASC--PSVSSAE---SVGPSSGGSCDRYGRSLS-----SRS-VAPT 346
            .::...|.|  .|.||.|..||  |:...|.   :||......|:   .:||     :|| :|..
Mouse   351 TSSTGTPSP--SASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCN---LNLSDYPPCARSNMAAL 410

  Fly   347 RTTPYSRPRVVSGSGSNG-SAGNASSTSPQPPSAPQTPTSLHS---TSTGSVSTSVSSSSGGGIG 407
            ::.|     .:|.||.|. .:|.||:|.|.....||...||.|   |.....|.|...:.||.:|
Mouse   411 QSYP-----GLSDSGYNRLQSGTASATQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLG 470

  Fly   408 SAPSTGCFSSSYAQSGFMSVDASPTASVFSYPSSWQSNGNYWNATSVPGP----------MPMNV 462
            |.|::   ...|......:..:|.:..:|......||:   :||.|:..|          .|...
Mouse   471 SFPTS---QFQYVMQAGNAASSSSSPHMFGGSHMQQSS---YNAFSLHNPYNLYGYNFPTSPRLA 529

  Fly   463 CSGRNISSHNS----PSPTNGS---PSYTTSSPSYTIHHLTPHSHQYNMAQT 507
            .|...:|:..|    .||:||:   ..|..:...:::|.::|.::......|
Mouse   530 ASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHSMHMISPSTNNQQATNT 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
byn	NP_524031.2	TBOX	86..268	CDD:238106	82/198 (41%)
Tbx15	NP_033349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..95		152/507 (30%)
		TBOX	113..308	CDD:238106	82/197 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..444		7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810