Protein Alignment SdhAL and frdA

DIOPT Version :10

• Sequence 1: NP_648523.1
• Gene: SdhAL / 39348
• FlyBaseID: FBgn0036222
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_418578.1
• Gene: frdA / 948667
• ECOCYCID: EG10330
• Length: 602
• Species: Escherichia coli
• Alignment Length: 623
• Identity: 233/623 - (37%)
• Similarity: 343/623 - (55%)
• Gaps: 67/623 - (10%)

  Fly    48 DAIVIGAGGAGMRAGFGLAE--KGFQTAIISKLFPTRSHTVAAQGGVNAALSNMDKDDWKYHFYD 110
            |..::||||||:||....|:  ...:.|:|||::|.|||||||:|| :||:: .|.|.::|||:|
E. coli     7 DLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGG-SAAVA-QDHDSFEYHFHD 69

  Fly   111 TVKGSDWLGDQNAIHYMCREAERAVCELDMYGMPFSRKPDGKIYQRPFGGQTLDYGKGGVARRAC 175
            ||.|.|||.:|:.:.|........:.:|:::|.|:||:|||.:..|.|||..::        |..
E. coli    70 TVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIE--------RTW 126

  Fly   176 ACADRTGHALIHTLYGQTLKHSDSCHYFVDYFVLDLIMSQGACVGCLAWKLDDGTFHRFLAKNTV 240
            ..||:||..::|||: ||.........|.::||||:::..|...|.:|..:.:||..:..|...|
E. coli   127 FAADKTGFHMLHTLF-QTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVV 190

  Fly   241 VAAGGCGRVYFSTTAGHTCTGDGNAWVSRQELPLMDMEFVQFHPTGIYGAGCLITEGVRGEGGFF 305
            :|.||.||||...|.|...||||........:||.||||||:||||:.|:|.|:|||.|||||..
E. coli   191 MATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGIL 255

  Fly   306 LNCKGERFMERYA---------PKAK--DLASRDVVARAMTMEVLAGNGCG-PLKDHVHLQLHHI 358
            :|..|.|:::.|.         ||.|  :|..||.|::|...|...||... |..|.|:|.|.|:
E. coli   256 VNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHL 320

  Fly   359 DAKIIKQRLPGIMVTARIFAKVDVTKEPVPVLPTVHYNMGGIPTDYKGRVVTIDENGKEQVVKGL 423
            ..|.:.:|||.|...|:.:..||..|||:||.||.||.||||.||          ...|..:|||
E. coli   321 GEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETD----------QNCETRIKGL 375

  Fly   424 YSCGETSCASVHGANRLGANSLLDLIIFGRVC---ALDIAANNCPGDKPP-QVEDKATEKSLDNF 484
            ::.||.|...:|||||||:|||.:|::|||:.   |.:.||....|::.. :.:....|:.|
E. coli   376 FAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRL--- 437

  Fly   485 KRLRCADGCIPTAVLRMELQRTMTKHAAVFREGKLLKEGLLKVAELCEQFKDIKTTDRTMVWNSN 549
            |.|...||....|.:|.|:...|.:...::|..:|:::.:.|:|||.|:||.::.||.:.|:|::
E. coli   438 KDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTD 502

  Fly   550 LVETLELQNMLANAVHIITAMENRKESRGSHAR-EDFKTRVDELDYGAPLAGQKKKPFEEHWRKH 613
            |:.|:||.:.|..|..:..:...||||||:|.| ::..|..|::::                .||
E. coli   503 LLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNF----------------LKH 551

  Fly   614 TMTFALGNKGCASIKYRPVVDTTLDSSVAPIPPAPRTY 651
            |:.|...: |...::|..|..|||       |||.|.|
E. coli   552 TLAFRDAD-GTTRLEYSDVKITTL-------PPAKRVY 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhAL	NP_648523.1	FAD_binding_2	37..651	CDD:481218	232/621 (37%)
frdA	NP_418578.1	PRK09231	2..583	CDD:236421	233/623 (37%)