DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhAL and FRD1

DIOPT Version :9

Sequence 1:	NP_648523.1	Gene:	SdhAL / 39348	FlyBaseID:	FBgn0036222	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_010867.3	Gene:	FRD1 / 856664	SGDID:	S000000773	Length:	470	Species:	Saccharomyces cerevisiae

Alignment Length:	506	Identity:	125/506 - (24%)
Similarity:	195/506 - (38%)	Gaps:	141/506 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IVIGAGGAGMRAGFGLAEK-GFQTAIISKLFPTRSHTVAAQGGVNAALSNMDKDDWKYHFY---- 109
            :|||.|.||:.|...|..| .....|:.|......:::.|..|:|.|.:...:     ||:
Yeast     7 VVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQR-----HFHIEDS 66

  Fly   110 ------DTVKGSDWLGDQNAIHYMCREAERAV--------CELDM------YGMPFSRKPDGKIY 154
                  ||:|.:...|.|..:..:..::..|:        .:||:      :.:..:.:..||:
Yeast    67 PRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKL- 130

  Fly   155 QRPFGGQTLDYGKGGVARRACACADRTGHALIHTLYGQTLKHSDSCHYFV----DYFVLDLIMSQ 215
                                     ..|..::..|.....|.:::....|    |..|:|:....
Yeast   131 -------------------------PPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKD 170

  Fly   216 GACVGCLAWKLDDGTFHRFLAKNTVVAAGGCG------------RVYFSTTAGHTCTGDGNAWVS 268
            |: :..:.::..:|..|...|.:.|..:||.|            .|...||.|...||||...:.
Yeast   171 GS-ISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQ 234

  Fly   269 RQELPLMDMEFVQFHPTGIYGAG-------CLITEGVRGEGGFFLN-CKGERFMERYAPKAKDLA 325
            :....|:||:.:|.||||.....       .|..|.:||.||..|| ..|.||:       .:|.
Yeast   235 KLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFV-------NELT 292

  Fly   326 SRDVVARAM----------TMEVLAGNGCGPLKDHVH-------LQLHHIDAKIIKQRLP----- 368
            :||||..|:          .:.|:.......||:::.       :|...:...:.:..||
Yeast   293 TRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQ 357

  Fly   369 ------------------GIMVTARIFAKVDVTKEPV----PVLPTVHYNMGGIPTDYKGRVVTI 411
                              |..|....|.. |||.|.|    .|.|.||:.|||...:.|.:|:
Yeast   358 LCEELQTYSSFTTKADPLGRTVILNEFGS-DVTPETVVFIGEVTPVVHFTMGGARINVKAQVI-- 419

  Fly   412 DENGK--EQVVKGLYSCGETSCASVHGANRLGANSLLDLIIFGRVCALDIA 460
               ||  |:::||||:.||.| ..||||||||.:|||:.::|||..|..||
Yeast   420 ---GKNDERLLKGLYAAGEVS-GGVHGANRLGGSSLLECVVFGRTAAESIA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhAL	NP_648523.1	PTZ00139	37..651	CDD:240286	125/506 (25%)
		NADB_Rossmann	68..459	CDD:304358	115/485 (24%)
		Succ_DH_flav_C	502..651	CDD:280980
FRD1	NP_010867.3	flavo_cyto_c	5..463	CDD:273816	122/501 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760