Protein Alignment SdhAL and SDH1

DIOPT Version :9

• Sequence 1: NP_648523.1
• Gene: SdhAL / 39348
• FlyBaseID: FBgn0036222
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_012774.1
• Gene: SDH1 / 853709
• SGDID: S000001631
• Length: 640
• Species: Saccharomyces cerevisiae
• Alignment Length: 653
• Identity: 367/653 - (56%)
• Similarity: 462/653 - (70%)
• Gaps: 23/653 - (3%)

  Fly     1 MNRLFLKRAGQHVTRSLLGPNGSRLLQVSCVRDASCKDEYSLIDHKFDAIVIGAGGAGMRAGFGL 65
            :::|.|.|..:..|.|.|.......:..|..|.|..|  |.:|||::|.:||||||||:||.|||
Yeast     9 LSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGK--YHIIDHEYDCVVIGAGGAGLRAAFGL 71

  Fly    66 AEKGFQTAIISKLFPTRSHTVAAQGGVNAALSNMDKDDWKYHFYDTVKGSDWLGDQNAIHYMCRE 130
            ||.|::||.|||||||||||||||||:||||.||.||:||:|.|||||||||||||::||||.||
Yeast    72 AEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTRE 136

  Fly   131 AERAVCELDMYGMPFSRKPDGKIYQRPFGGQTLDYGKGGVARRACACADRTGHALIHTLYGQTLK 195
            |.:::.||:.||:||||..:||||||.|||||.:||||..|.|.||.||||||||:||||||.|:
Yeast   137 APKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALR 201

  Fly   196 HSDSCHYFVDYFVLDLIMSQGACVGCLAWKLDDGTFHRFLAKNTVVAAGGCGRVYFSTTAGHTCT 260
            |  ..|:|::||.|||:...|..||.:|:..:|||.|||.|..|::|.||.||.|||.|:.||||
Yeast   202 H--DTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCT 264

  Fly   261 GDGNAWVSRQELPLMDMEFVQFHPTGIYGAGCLITEGVRGEGGFFLNCKGERFMERYAPKAKDLA 325
            |||||.|||...||.|:|||||||:||||:|||||||.||||||.:|.:||||||||||.|||||
Yeast   265 GDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLA 329

  Fly   326 SRDVVARAMTMEVLAGNGCGPLKDHVHLQLHHIDAKIIKQRLPGIMVTARIFAKVDVTKEPVPVL 390
            .||||:||:|||:..|.|.|..|||::|||.|:..:::|:|||||..||.|||.|||||||:|::
Yeast   330 CRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPII 394

  Fly   391 PTVHYNMGGIPTDYKGRVVTID-ENGKEQVVKGLYSCGETSCASVHGANRLGANSLLDLIIFGRV 454
            ||||||||||||.:.|..:||| |.|:::|:.||.:|||.:|.||||||||||||||||::|||.
Yeast   395 PTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRA 459

  Fly   455 CALDIAANNCPGDKPPQVEDKATEKSLDNFKRLRCADGCIPTAVLRMELQRTMTKHAAVFREGKL 519
            .|..:|....||.....:.....::|:.|..:||.|:|...||.:||.:::||.|..:|||....
Yeast   460 VAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSS 524

  Fly   520 LKEGLLKVAELCEQFKDIKTTDRTMVWNSNLVETLELQNMLANAVHIITAMENRKESRGSHARED 584
            |.||:..:..:.:.|.|:|||||:|:|||:|||||||||:|..|.....:..|||||||:|||||
Yeast   525 LDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHARED 589

  Fly   585 FKTRVDELDYGAPLAGQKKKPFEEHWRKHTMTFALGNKGCASIKYRPVVDTTLDSSVAP-IPPAP 648
            :..|.|                 |||.|||:::........::|||.|:|.|||....| :||..
Yeast   590 YPNRDD-----------------EHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTV 637

  Fly   649 RTY 651
            |.|
Yeast   638 RAY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhAL	NP_648523.1	PTZ00139	37..651	CDD:240286	357/615 (58%)
		NADB_Rossmann	68..459	CDD:304358	260/391 (66%)
		Succ_DH_flav_C	502..651	CDD:280980	63/149 (42%)
SDH1	NP_012774.1	SdhA	46..640	CDD:393461	356/612 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I971
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	O	PTHR11632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1604
TreeFam	1	0.960	-	-
	10	9.730