DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhAL and SDHA

DIOPT Version :9

Sequence 1:	NP_648523.1	Gene:	SdhAL / 39348	FlyBaseID:	FBgn0036222	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_016865174.1	Gene:	SDHA / 6389	HGNCID:	10680	Length:	785	Species:	Homo sapiens

Alignment Length:	613	Identity:	382/613 - (62%)
Similarity:	473/613 - (77%)	Gaps:	9/613 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SCKDEYSLIDHKFDAIVIGAGGAGMRAGFGLAEKGFQTAIISKLFPTRSHTVAAQGGVNAALSNM 99
            |...:|.::||:|||:|:||||||:||.|||:|.||.||.::|||||||||||||||:||||.||
Human    50 SISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNM 114

  Fly   100 DKDDWKYHFYDTVKGSDWLGDQNAIHYMCREAERAVCELDMYGMPFSRKPDGKIYQRPFGGQTLD 164
            ::|:|::|||||||||||||||:|||||..:|..||.||:.|||||||..|||||||.||||:|.
Human   115 EEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLK 179

  Fly   165 YGKGGVARRACACADRTGHALIHTLYGQTLKHSDSCHYFVDYFVLDLIMSQGACVGCLAWKLDDG 229
            :||||.|.|.|..||||||:|:|||||::|::..|  |||:||.|||:|..|.|.|.:|..::||
Human   180 FGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTS--YFVEYFALDLLMENGECRGVIALCIEDG 242

  Fly   230 TFHRFLAKNTVVAAGGCGRVYFSTTAGHTCTGDGNAWVSRQELPLMDMEFVQFHPTGIYGAGCLI 294
            :.||..|||||||.||.||.|||.|:.||.||||.|.::|..||..|:|||||||||||||||||
Human   243 SIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLI 307

  Fly   295 TEGVRGEGGFFLNCKGERFMERYAPKAKDLASRDVVARAMTMEVLAGNGCGPLKDHVHLQLHHID 359
            |||.|||||..:|.:||||||||||.||||||||||:|:||:|:..|.||||.||||:|||||:.
Human   308 TEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLP 372

  Fly   360 AKIIKQRLPGIMVTARIFAKVDVTKEPVPVLPTVHYNMGGIPTDYKGRVVTIDENGKEQVVKGLY 424
            .:.:..|||||..||.|||.|||||||:|||||||||||||||:|||:|:. ..||::|:|.|||
Human   373 PEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLR-HVNGQDQIVPGLY 436

  Fly   425 SCGETSCASVHGANRLGANSLLDLIIFGRVCALDIAANNCPGDKPPQVEDKATEKSLDNFKRLRC 489
            :|||.:||||||||||||||||||::|||.|||.|..:..||||.|.::..|.|:|:.|..:||.
Human   437 ACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRF 501

  Fly   490 ADGCIPTAVLRMELQRTMTKHAAVFREGKLLKEGLLKVAELCEQFKDIKTTDRTMVWNSNLVETL 554
            |||.|.|:.||:.:|::|..||||||.|.:|:||..|:::|....|.:||.||.||||::|||||
Human   502 ADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETL 566

  Fly   555 ELQNMLANAVHIITAMENRKESRGSHAREDFKTRVDELDYGAPLAGQKKKPFEEHWRKHTMTFAL 619
            ||||::..|:..|...|.||||||:|||||:|.|:||.||..|:.||:||||||||||||:::..
Human   567 ELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVD 631

  Fly   620 GNKGCASIKYRPVVDTTLDSSVAPIPPA 647
            ...|..|      |:..|.::..|..||
Human   632 VGTGKVS------VELVLTTAQHPHGPA 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhAL	NP_648523.1	PTZ00139	37..651	CDD:240286	381/611 (62%)
		NADB_Rossmann	68..459	CDD:304358	269/390 (69%)
		Succ_DH_flav_C	502..651	CDD:280980	74/146 (51%)
SDHA	XP_016865174.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.957091	Normalized mean entropy	S148
OMA	1	1.010	-	-		QHG60640
OrthoDB	1	1.010	-	-		D171709at33208
OrthoFinder	1	1.000	-	-		FOG0002411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100447
Panther	1	1.100	-	-	O	PTHR11632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.740