DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11588 and Tmx4

DIOPT Version :9

Sequence 1:	NP_001261729.1	Gene:	CG11588 / 39347	FlyBaseID:	FBgn0036221	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_083424.1	Gene:	Tmx4 / 52837	MGIID:	106558	Length:	335	Species:	Mus musculus

Alignment Length:	242	Identity:	53/242 - (21%)
Similarity:	83/242 - (34%)	Gaps:	71/242 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SSYLMAEYGDGL-----------ITRIDEGNWKEVLTGEWLLLICSSHQPSC----GDWK--AVL 86
            :::|.|...:||           :..:...||..|:.|||:|...:...|||    .:|:  |..
Mouse    12 AAWLAAAAAEGLEQAALPAEESRVQPMTASNWTLVMEGEWMLKFYAPWCPSCQQTDSEWETFAKN 76

  Fly    87 YQLASTSMGCLDVDLAFGDLSTNFWLRGRFSAFREANVYHVVDGEFRRLSSSHDTNSILNLLLLR 151
            .:....|:|.:||....|       |.|||........:|..||.|||.........:.|.:|.:
Mouse    77 GETLQISVGKVDVIQEPG-------LSGRFFVTTLPAFFHAKDGIFRRYRGPGIYEDLQNYILEK 134

  Fly   152 EWSELPPMPFWLHPTS---------------TWSTSAEFVLKTAVDLKDLDILGRNAWKTALILD 201
            :|..:.|:..|..|.|               .|.....|.:          .||..||     ..
Mouse   135 KWQSVEPLTGWKSPASLTMSGMAGLFSISGKIWHLHNYFTV----------TLGIPAW-----CS 184

  Fly   202 LIFFIVTPYI----LWLTIMTTTENMMVNDEFKLGPTESSSPLPLKS 244
            .:||::...:    :.|.::..:|...|             |||..|
Mouse   185 YVFFVIATLVFGLFMGLILVVISECFCV-------------PLPRAS 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11588	NP_001261729.1	Thioredoxin_like	51..148	CDD:294274	28/102 (27%)
Tmx4	NP_083424.1	Thioredoxin_like	33..133	CDD:294274	28/106 (26%)
Tmx4	NP_083424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870