DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11588 and p4hb

DIOPT Version :9

Sequence 1:	NP_001261729.1	Gene:	CG11588 / 39347	FlyBaseID:	FBgn0036221	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001034820.1	Gene:	p4hb / 395048	XenbaseID:	XB-GENE-494070	Length:	506	Species:	Xenopus tropicalis

Alignment Length:	312	Identity:	64/312 - (20%)
Similarity:	109/312 - (34%)	Gaps:	108/312 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLILLLSVFG----VIPNAMIPKSPVNIDVCPRSSRKSESSYLMAEYGDGLITRIDEGNWKEVLT 64
            |.:||   ||    ::..|.||                       |..|.|:.:.|  |:.|.|.
Frog     3 RAVLL---FGCSLLIVARANIP-----------------------EERDVLVLKKD--NFDEALK 39

  Fly    65 GEWLLLICSSHQPSCGDWKAVL--YQLASTSMGCLDVDLAFG--------DLSTNFWLRG----- 114
             ::..::...:.|.||..||:.  |:.|:..:....:.:..|        ||:..|.:||
Frog    40 -QYPFILVEFYAPWCGHCKALAPEYEKAAGVLKSEGLPIRLGKVDATEESDLAQEFGVRGYPTIK 103

  Fly   115 -----------RFSAFREANVYHVVDGEFRRLSSSHDT-NSILNLLLLREWSELPPMPFWLHPTS 167
                       .:||.|||  ..:|:...:|...:..| .....:..|.:.||:..:.|:..|.
Frog   104 FFKNGDKASPKEYSAGREA--ADIVNWLKKRTGPAASTLGDEAGVAALVDSSEVAVIGFFKDPA- 165

  Fly   168 TWSTSAEFVLKTAVDLKDLD--------------------IL------GRNAWKTALILDLIFFI 206
              |..|:..|:.|..:.|:.                    :|      ||||::..:..:.:...
Frog   166 --SEPAKVFLQAAEAVDDIPFGITSSEAAFSKYELGKDGIVLFKKFDEGRNAYEGDITKEEVLSF 228

  Fly   207 VTPYILWLTIMTTTENMMVNDEFKLGPTESSSPLPLKSISKIKSTTPIFLQK 258
            :....|.|.|           ||    ||.::|:...  .:||:....||.|
Frog   229 IKANRLPLVI-----------EF----TEQTAPMIFG--GEIKTHILFFLPK 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11588	NP_001261729.1	Thioredoxin_like	51..148	CDD:294274	25/123 (20%)
p4hb	NP_001034820.1	ER_PDI_fam	25..474	CDD:273457	55/264 (21%)
		pdi_dom	29..133	CDD:273454	23/108 (21%)
		PDI_b_family	137..232	CDD:239279	16/97 (16%)
		PDI_b'_family	244..347	CDD:239280	6/22 (27%)
		PDI_a_PDI_a'_C	368..470	CDD:239293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910