DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11588 and pdia2

DIOPT Version :9

Sequence 1:	NP_001261729.1	Gene:	CG11588 / 39347	FlyBaseID:	FBgn0036221	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001307463.1	Gene:	pdia2 / 394023	ZFINID:	ZDB-GENE-040426-705	Length:	555	Species:	Danio rerio

Alignment Length:	248	Identity:	52/248 - (20%)
Similarity:	93/248 - (37%)	Gaps:	58/248 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DVCPRSSRKSESSYLMAEYGDGLITRIDEGNWKEVLTGEWLLLICSSHQPSCGDWKAVLYQLAST 92
            |..|....|::.   :.|..|.||  :...|:...|:....||: ..:.|.||.
Zfish    40 DTEPEKPEKTDE---ITEDKDVLI--LHSVNFDRALSENKYLLV-EFYAPWCGH----------- 87

  Fly    93 SMGCLDVDLAFGDLSTNFWLRGRFSAFREANVYHVVDGEFRRLSSSHDTNSILNLLLLREWSELP 157
               |..::..:.:::..  |:...|..|.|.|..:   |.:.|:|....:|...|...:|.:...
Zfish    88 ---CRSLEPIYAEVAGQ--LKNASSEVRLAKVDAI---EEKELASEFSVDSFPTLKFFKEGNRQN 144

  Fly   158 PMPF-----------WLH----PTSTWST---SAEFVLKTAVDL-----KDLDILGRNAWK---- 195
            ...|           ||.    |::|...   |||.:|:....|     |||:  |..|..
Zfish   145 ATTFFGKRTLKGIKRWLEKHTAPSATVLNDVKSAEALLEANEVLVVGFFKDLE--GEKAKTFYDV 207

  Fly   196 TALILDLIFFIVTPYILWLTIMTTTENMMVNDEFKLGPTESSSPLPLKSISKI 248
            |.:.:|:.|.|.:...|:......|:::::..:|    .|..:.:||...:|:
Zfish   208 TLIAVDVNFGITSDPELFKKYEVKTDSLVLFKKF----DERRADMPLSDETKL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11588	NP_001261729.1	Thioredoxin_like	51..148	CDD:294274	18/96 (19%)
pdia2	NP_001307463.1	ER_PDI_fam	56..512	CDD:273457	48/229 (21%)
		PDI_a_family	65..161	CDD:239259	20/115 (17%)
		PDI_b_family	169..268	CDD:239279	22/94 (23%)
		PDI_b'_family	280..382	CDD:239280
		PDI_a_PDI_a'_C	403..505	CDD:239293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910