Protein Alignment CG11588 and ERP44

DIOPT Version :9

• Sequence 1: NP_001261729.1
• Gene: CG11588 / 39347
• FlyBaseID: FBgn0036221
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_055866.1
• Gene: ERP44 / 23071
• HGNCID: 18311
• Length: 406
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 44/229 - (19%)
• Similarity: 64/229 - (27%)
• Gaps: 95/229 - (41%)

  Fly     9 LSVFGVIPNAMIPK--SPVNIDVCPRSSRKSESSYLMAEYGDGLITRID-EGNW----------- 59
            ||.||.:..   |:  |..||...|......:..||      |.:|..| ..||
Human   192 LSAFGDVSK---PERYSGDNIIYKPPGHSAPDMVYL------GAMTNFDVTYNWIQDKCVPLVRE 247

  Fly    60 -----KEVLTGEWLLLICSSH-----------------------------QPSCGDWKAVLYQLA 90
                 .|.||.|.|..:...|                             ...|..::..|..:.
Human   248 ITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQ 312

  Fly    91 STSMGC--LDVD-----LAFGDLSTNFWLRGRFSAFREANVYHVVDGEFRR-------------- 134
            .|...|  :.:|     ..|||.. :..:.|:...|    |:.:..|:..|
Human   313 KTPADCPVIAIDSFRHMYVFGDFK-DVLIPGKLKQF----VFDLHSGKLHREFHHGPDPTDTAPG 372

  Fly   135 -----LSSSHDTNSILNL-------LLLREWSEL 156
                 ::||...:|...|       .|||:..||
Human   373 EQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11588	NP_001261729.1	Thioredoxin_like	51..148	CDD:294274	27/175 (15%)
ERP44	NP_055866.1	PDI_a_ERp44	29..136	CDD:239294
		PDI_b_ERp44	144..234	CDD:239368	14/50 (28%)
		Interaction with ITPR1. /evidence=ECO:0000250	236..285		7/48 (15%)
		PDI_b'_ERp44	245..355	CDD:239370	17/114 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..387		2/26 (8%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	403..406		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910