DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sprn and ccdc181

DIOPT Version :9

Sequence 1:	NP_001163425.2	Gene:	Sprn / 39344	FlyBaseID:	FBgn0036218	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001122012.1	Gene:	ccdc181 / 566663	ZFINID:	ZDB-GENE-060503-312	Length:	497	Species:	Danio rerio

Alignment Length:	506	Identity:	102/506 - (20%)
Similarity:	175/506 - (34%)	Gaps:	152/506 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ETFSSEESQASDCNQPLDVQSPKLTTNIEESFKVDCKLSLNTLLSPINITDP----LRKQIDFQC 86
            |..:|...|..|  :.||.:...:...|:|:.|            .:...||    .|:::.|:.
Zfish    90 ELITSPHLQNDD--EDLDDEKKYILDKIQEANK------------QLQDQDPPDQMRRRRLQFKD 140

  Fly    87 KLGDLSFFGPVMCSISEFNKEEQTMEPYFIQELDMACAGQ----EVEQVAEENVFETGPQ----- 142
            .|.||      :....||:.:|..:..:...|.:...:||    .:.| .|||..:.||:
Zfish   141 TLVDL------VVPAHEFDAQESNIASFGDVEEEQEVSGQMQRLRISQ-REENQNKDGPEDEHNE 198

  Fly   143 -------------------LKLPENQPINDSITTETNETK---LPSTEALNVLNLAEFSEPVMEK 185
                               ||..|:|.:...:....|:.:   |..||:...||          |
Zfish   199 GGKEGRVLIEKDGKFDLVSLKEVESQGLLPPLPVSHNDNQRAPLRQTESGQHLN----------K 253

  Fly   186 SNISIEEVNLTGAEEINEPISDEPNSQLVESAAKLQPKSLGIQIPPLQIEDLISPLVEQPKIATK 250
            |.:|....|||         |..|.|.          :||.|..||.:..:       :|..|..
Zfish   254 SPVSSPRQNLT---------SPFPPSN----------ESLYIPKPPPKHRN-------RPSSARP 292

  Fly   251 LGVISFLTGNKLAL-----TPSVRLSFGDRVTTRTNKKSKEI---VQQQASKALKALISVFTMQR 307
            ....:::.|.|..:     .||       ..|...:.:.||:   :||:..:..|.    ..|::
Zfish   293 SQRGTWVQGTKRRVQSANGAPS-------HATFTLSPQQKELLAKLQQRRERQAKE----DEMKK 346

  Fly   308 RLEASQCDNSNNSR-----SKRFEQLKSSLTFSRVFRQNIFQPTSKIESRQQNTDANSLESGEPN 367
            |.|..|....|...     .::.|||   |...||.:.   |...::..|:        :.|:|.
Zfish   347 REEEEQKRQENEIAFQSWLMRKREQL---LEERRVHKA---QEMERMSCRR--------DCGDPE 397

  Fly   368 FKSTSAYKEPLPIPYRQDAGEGLTCNGLNVSKDSVFSEVSESDVSETHNKLFAMKKTQEGLSSTR 432
                .|:|..|.....|...:....:...:.|||.|...|..:..:...:....|::::     |
Zfish   398 ----EAFKIWLQKKQEQQFKDKQLEDMKRLEKDSGFCLHSREESEKAFRQWLRRKRSEK-----R 453

  Fly   433 SIGELSNILNNGRVLFSQPVR----LFC-FNKLKEWKRQGKVPRFHESPYR 478
            :..:|:...:...:|..:..|    |.| .|::|.:       ||.: |||
Zfish   454 AEHQLARERSRRLMLEERRARRMHDLLCTVNEIKPF-------RFSD-PYR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sprn	NP_001163425.2	PH-like	446..562	CDD:302622	11/38 (29%)
ccdc181	NP_001122012.1	Mpp10	18..>227	CDD:281935	32/157 (20%)
ccdc181	NP_001122012.1	DUF4207	<360..476	CDD:290615	24/138 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960