DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CCNE2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_477097.1	Gene:	CCNE2 / 9134	HGNCID:	1590	Length:	404	Species:	Homo sapiens

Alignment Length:	256	Identity:	78/256 - (30%)
Similarity:	127/256 - (49%)	Gaps:	40/256 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 DISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRF-LSQMAVVRSKLQLVGTAAMYIAAKYE 293
            |:...|||||:|||:||.|.|.|..||.||:..:.||| |:|..:.::.|||:|..:::||:|.|
Human   136 DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLE 200

  Fly   294 EIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYA---VLCDMPEKL-- 353
            |||.|::.||.::||.:.::..:||||.:|||.|.::||..|...::|.:.   .|.|.|:.|
Human   201 EIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLP 265

  Fly   354 -----------KYMTLYISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLE------ 401
                       :.:.|.|..:..:|.:..:....:|....|:.:.:...|:| |....|
Human   266 QYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLE-WDSISECVDWMV 329

  Fly   402 -------EITTYKLEDLKTVVL---HLCHTHKTAKELNTQAMREKYNR-DTYKKVAMMESV 451
                   ..:..||:..|.:.:   |...||     .|..||.|:.|. :|::|...:..|
Human   330 PFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH-----TNYLAMLEEVNYINTFRKGGQLSPV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	47/102 (46%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	28/148 (19%)
CCNE2	NP_477097.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Cyclin_N	112..239	CDD:278560	47/102 (46%)
		Cyclin_C	241..361	CDD:281044	21/125 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750