DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CCNG2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_004345.1	Gene:	CCNG2 / 901	HGNCID:	1593	Length:	344	Species:	Homo sapiens

Alignment Length:	303	Identity:	70/303 - (23%)
Similarity:	127/303 - (41%)	Gaps:	54/303 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 MDILEYFRESEKKHRPKPLYMRRQKDIS-------------HNMRSILIDWLVEVSEEYKLDTET 256
            :.:|..:.|.|::.:|      |:|.:|             ..:|:..::.|..::..:...|||
Human    18 LGLLNVYLEQEERFQP------REKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTET 76

  Fly   257 LYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKY--EEIYPPEVGEFVFLTDDSYTKAQVLRM 319
            ..|:|..|||||:.|.|....|..:|..:..:||:.  |:...|...:.:.::....|.:.:.||
Human    77 FVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRM 141

  Fly   320 EQVILKILSFDLCTPTAYVFINTY--AVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSA 382
            |::|.:.|.::|...||..|::.|  .:||...|:.:.::|...|..|......|     :.|.|
Human   142 EKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRL-----IFSKA 201

  Fly   383 SVA-LARHILGMEMWTPRLEEITTYKLEDLKTV----VLHLCHTHKTAKELNTQAMREKYNRDTY 442
            ..: ||..:|.:|             :|.||:|    :|.|...|....:......||..:
Human   202 KPSVLALCLLNLE-------------VETLKSVELLEILLLVKKHSKINDTEFFYWRELVS---- 249

  Fly   443 KKVAMMESVEMSKDDFDQLCEAYNCKQKEDEHQQ----PDINT 481
            |.:|...|.|..|.|..:|....:.:..::.|..    |::.|
Human   250 KCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPT 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	33/140 (24%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	28/122 (23%)
CCNG2	NP_004345.1	CYCLIN_CCNG2	55..150	CDD:410287	25/94 (27%)
CCNG2	NP_004345.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740