DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CCNF

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001752.2	Gene:	CCNF / 899	HGNCID:	1591	Length:	786	Species:	Homo sapiens

Alignment Length:	310	Identity:	86/310 - (27%)
Similarity:	152/310 - (49%)	Gaps:	29/310 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 NDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTET 256
            |..|..|||......:.:.|:.|:...:.:...:  ||.::..||.|||||||||:......:..
Human   268 NANQLGLEVRASSEIVCQLFQASQAVSKQQVFSV--QKGLNDTMRYILIDWLVEVATMKDFTSLC 330

  Fly   257 LYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKY--EEIYPPEVGEFVFLTDDSYTKAQVLRM 319
            |:|:|..:||:|.:..|.|.:|||:|.|.|.|..::  :||.  .:.|.|:|||::|....::||
Human   331 LHLTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEIL--TIREAVWLTDNTYKYEDLVRM 393

  Fly   320 EQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQ-YLPSLMSSAS 383
            ...|:..|...:..||...:......|..:..:.:::..::.||||:  .|.|. |.|:.:::|:
Human   394 MGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLL--HTSLSAYAPARLAAAA 456

  Fly   384 VALARHILGM-EMWTPRLEEITTYKLEDLKTVVLHLCHTHKTA---------KELNTQAMREKYN 438
            :.|||...|. :.||.:|.::|.:..|||...||.|   ||..         ::::..|:::::.
Human   457 LLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSL---HKKCFHDDAPKDYRQVSLTAVKQRFE 518

  Fly   439 RDTYKKVAMMESVEMSKDDFDQLCEAYNCKQKEDEHQQPDINTKSNVNLF 488
            ...|.:::..|.:     .:.|||.|....|  |....|...:...::.|
Human   519 DKRYGEISQEEVL-----SYSQLCAALGVTQ--DSPDPPTFLSTGEIHAF 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	42/127 (33%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	30/126 (24%)
CCNF	NP_001752.2	Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:10716937	20..28
		F-box domain	29..76
		FBOX	35..73	CDD:197608
		TPR	<88..>146	CDD:223861
		SLR repeat	88..112	CDD:276807
		Cyclin_N	281..406	CDD:278560	42/128 (33%)
		Cyclin_C	421..531	CDD:281044	28/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..593
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:10716937	568..574
		PEST	582..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910