DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CCNB1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_114172.1	Gene:	CCNB1 / 891	HGNCID:	1579	Length:	433	Species:	Homo sapiens

Alignment Length:	473	Identity:	129/473 - (27%)
Similarity:	207/473 - (43%)	Gaps:	105/473 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NKEN------PGIK-IPAGVKNTKQP-------LAVIGGKAE---------KNALAPRANFAVLN 53
            |.||      .|.| :|.....|.:|       |..||.|..         |....|.|...|:
Human    12 NAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVI- 75

  Fly    54 GNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLA 118
             :..:|:|..||.:                     :|||       .|.|...:.:..|
Human    76 -DKKLPKPLEKVPM---------------------LVPV-------PVSEPVPEPEPEP------ 105

  Fly   119 SLVDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQS------SDI-----S 172
                 |...||         :..|...|:.| |..||..::.|.....:.      ||:     .
Human   106 -----EPEPVK---------EEKLSPEPILV-DTASPSPMETSGCAPAEEDLCQAFSDVILAVND 155

  Fly   173 VGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRS 237
            |..|.|..|.                ...:|..||..|.|:.|::...:|.|: ..::::.|||:
Human   156 VDAEDGADPN----------------LCSEYVKDIYAYLRQLEEEQAVRPKYL-LGREVTGNMRA 203

  Fly   238 ILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGE 302
            |||||||:|..:::|..||:|::|..:|||:....|.:..|||||..||:||:||||:||||:|:
Human   204 ILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGD 268

  Fly   303 FVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLME 367
            |.|:||::|||.|:.:||..||:.|:|.|..|....|:...:.:.::..:...:..|:.||::::
Human   269 FAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLD 333

  Fly   368 GETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQA 432
            .: .:.:.||.:::.:..||..||....|||.|:...:|..|.|..|:.||........:..|:.
Human   334 YD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKH 397

  Fly   433 M--REKYNRDTYKKVAMM 448
            |  :.||....:.|::.:
Human   398 MTVKNKYATSKHAKISTL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	59/125 (47%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	26/117 (22%)
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..47		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..116		6/42 (14%)
		Interaction with CDK2	169..177		3/7 (43%)
		Cyclin_N	173..298	CDD:278560	59/125 (47%)
		Interaction with CDK2	258..261		2/2 (100%)
		Cyclin_C	300..418	CDD:281044	26/117 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650