DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CLB2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_015444.1	Gene:	CLB2 / 856236	SGDID:	S000006323	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	472	Identity:	122/472 - (25%)
Similarity:	209/472 - (44%)	Gaps:	88/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RDVRNLNVDENVEYGAKKSNV-VPVVEQFKT--------------FSVYEDNNDTQVAPSGKSLA 118
            |:|:.|.::.......:|||. .|.:..||:              |:....:..|......::|.
Yeast    21 RNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTLK 85

  Fly   119 S----------LVDKENHD---VKFGA---------------------GQKELVDYDLDSTPMSV 149
            .          |.||||.|   .:|||                     ..||::.:|......|.
Yeast    86 ENGIQLPKNNLLDDKENQDPSSQQFGALTSIKEGRAELPANISLQESSSAKEIIQHDPLKGVGSS 150

  Fly   150 TDV------QSPMSVDRSILGVIQS-SDISVGTETGVSPTGRVKELPPR------NDRQRF---- 197
            |:|      ...:...||.|.|..: |:...|.:..:| |...:|||.:      |.::.:
Yeast   151 TEVVHNSVENEKLHPARSQLQVRNTESETDSGKKRPIS-TIVEQELPKKFKVCDENGKEEYEWED 214

  Fly   198 ---------LEVVQYQMDILEYFRESEKKHRPK--PLYMRRQKDISHNMRSILIDWLVEVSEEYK 251
                     ..|.:|..||.||..:.|....||  .||..|.   .|..|.||::|||::..::.
Yeast   215 LDAEDVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRN---IHQNRDILVNWLVKIHNKFG 276

  Fly   252 LDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQV 316
            |..|||||::..:||||.:..|...|||||||:.::||:||||:|.|.:..|...||.:.|:.::
Yeast   277 LLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEI 341

  Fly   317 LRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSS 381
            ...|:.|||.|.|:|..|....|:...:...|...:.:.:..::.|:||::.. ::..||||.::
Yeast   342 KEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFR-FIGILPSLCAA 405

  Fly   382 ASVALARHILGMEMWTPRLEEIT-TYKLEDLKTVVLHLCHTHKTAKELNTQAMREKYNRDTYKKV 445
            |::.::|.:||...|...|...: .|..|:| ..|.|:...:..:..::.:..| ||....:.|.
Yeast   406 AAMFMSRKMLGKGKWDGNLIHYSGGYTKEEL-APVCHMIMDYLVSPIVHDEFHR-KYQSRRFMKA 468

  Fly   446 AMME---SVEMSKDDFD 459
            :::.   ::::.|:.:|
Yeast   469 SIISVQWALKVRKNGYD 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	53/127 (42%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	25/119 (21%)
CLB2	NP_015444.1	COG5024	8..487	CDD:227357	122/472 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	7	6.740