DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CLN2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_015067.1	Gene:	CLN2 / 855819	SGDID:	S000006177	Length:	545	Species:	Saccharomyces cerevisiae

Alignment Length:	196	Identity:	45/196 - (22%)
Similarity:	80/196 - (40%)	Gaps:	43/196 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 QYQMDILEYFRESEKKHRPKPLYMRRQKDISH-NMRSILIDWLVEVSEEYKLDTETLYLSVFYLD 265
            :|..:|.........|.:|.|..:.:|.:::. ..||.:|.:|.|:|...::.....:.||...|
Yeast    39 EYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVETRSNIITFLFELSVVTRVTNGIFFHSVRLYD 103

  Fly   266 RFLSQMAVVRSKLQLVGTAAMYIAAK---------YEEIYP--------------PEVGEFVFLT 307
            |:.|:..|:|.:.:||....:::|||         ...:.|              |.:.|.|...
Yeast   104 RYCSKRIVLRDQAKLVVATCLWLAAKTWGGCNHIINNVVIPTGGRFYGPNPRARIPRLSELVHYC 168

  Fly   308 DDS--YTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGET 370
            .|.  :.::..|:||:.||..|::::..|    .||.|             .|.:.|..||:.|.
Yeast   169 GDGQVFDESMFLQMERHILDTLNWNIYEP----MINDY-------------VLNVDENCLMQYEL 216

  Fly   371 Y 371
            |
Yeast   217 Y 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	34/151 (23%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	10/38 (26%)
CLN2	NP_015067.1	COG5024	33..524	CDD:227357	45/196 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840