Protein Alignment CycA and CCNB3

DIOPT Version :10

• Sequence 1: NP_524030.2
• Gene: CycA / 39340
• FlyBaseID: FBgn0000404
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: XP_016885402.1
• Gene: CCNB3 / 85417
• HGNCID: 18709
• Length: 1404
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 153/534 - (28%)
• Similarity: 242/534 - (45%)
• Gaps: 106/534 - (19%)

  Fly     8 QDMSNKENPGIKIPAGVKNT--KQPLAVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFRD 70
            :.:..:|.|.||     |.|  |:|||:     :.:.:.....|..:...|..| ..||...|::
Human   894 ESLDLQEKPSIK-----KETLLKKPLAL-----KMSTINEAVLFEDMIALNEKP-TTGKELSFKE 947

  Fly    71 --------------------VRNLNVDENVEYGA-----KKSNVVPVVEQFKTFSV-----YEDN 105
                                |..:....||...|     .||::..:....|:.::     :||.
Human   948 PLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDM 1012

  Fly   106 NDTQVAP-SGKSLA---SLVDKENHDVK-------FGAGQKELVDYDLDSTPMSVTD---VQSPM 156
            ......| :||.|:   .|..:|:...|       |...|.....|...:||.|:|:   :.:..
Human  1013 ITLNEKPTTGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMT 1077

  Fly   157 SVDRSILGVIQSSDISVGTETGVSP--TGRVKE-LPPRNDRQR------FLEVVQYQMDILEYFR 212
            ||.:| ....:||.....::..|||  .|..|| :.||.|...      |..:  |..:|..|.:
Human  1078 SVGKS-RTTTESSACESASDKPVSPQAKGTPKEQITPREDIDEDSSDPSFNPM--YAKEIFSYMK 1139

  Fly   213 ESE-----KKHRPKPL--YMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQ 270
            |.|     :.|....|  ||.||.:|:.:||:||:||||||...:::..|||||:|..:|.:|.:
Human  1140 EREIEETAQSHEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMK 1204

  Fly   271 MAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPT 335
            ....:.||||:|..|..||||:||...|.|.:||::.||:|.:::||.||..||.:|..|:..|.
Human  1205 AVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPI 1269

  Fly   336 AYVFINTYAVLCDMPEKLKYMTL--YISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTP 398
            ||.|:..|| .| :...:|.:||  ||.|::|.|.. |:|...|.:::||:.||.::..:..|.|
Human  1270 AYHFLRRYA-RC-IHTNMKTLTLSRYICEMTLQEYH-YVQEKASKLAAASLLLALYMKKLGYWVP 1331

  Fly   399 RLEEITTYKLEDLKTVVLHLCHTHKTAKELN----------TQAMREKYNRDTYKKVAMMESVEM 453
            .||..:.|.:.:|          |...::||          .:|:..||:...:.:||.:.:::|
Human  1332 FLEHYSGYSISEL----------HPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDM 1386

  Fly   454 SKDDFDQLCEAYNC 467
            .|     |.|..||
Human  1387 LK-----LEEILNC 1395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	CYCLIN_CCNA_rpt1	202..329	CDD:410208	56/133 (42%)
		Cyclin_C	334..450	CDD:397230	36/127 (28%)
CCNB3	XP_016885402.1	CYCLIN_CCNB3_rpt1	1116..1264	CDD:410212	58/149 (39%)
		CYCLIN_SF	1268..1382	CDD:477360	36/126 (29%)