DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and ccnb1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_571588.1	Gene:	ccnb1 / 58025	ZFINID:	ZDB-GENE-000406-10	Length:	398	Species:	Danio rerio

Alignment Length:	460	Identity:	129/460 - (28%)
Similarity:	213/460 - (46%)	Gaps:	92/460 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MSNKENPGIKIPAGVKNTKQPLAVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFRDVRNL 74
            :::.||         :|.....||:   |.|..|.|||....: |||...|.|.|      .:.:
Zfish    12 LASSEN---------QNALPGKAVV---ANKPGLRPRAALGEI-GNNPQTRQALK------KKEV 57

  Fly    75 NVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLASLVDKENHDVKFGAGQKELVD 139
            .|....|...:|:   |||:|.|..|                     .|..|.||.
Zfish    58 KVAPAAEVVVEKA---PVVQQPKKDS---------------------PKVQHGVKV--------- 89

  Fly   140 YDLDSTPMSVTDVQSPMSVDRSILGVIQS------SDISVGTETGVSPTGRVKELPPRNDRQRFL 198
                     |::..||:.::.|  |....      ||:.:          .:|:: ..:|....:
Zfish    90 ---------VSEPSSPVPMETS--GCASDDLCQAFSDVLL----------NIKDV-DADDYDNPM 132

  Fly   199 EVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLYLSVFY 263
            ...:|..||..|.|:.|.:...:|.|: ..|:::.|||:|||||||:|..:::|..||:|::|..
Zfish   133 LCSEYVKDIYLYLRQLETEQAVRPKYL-AGKEVTGNMRAILIDWLVQVQIKFRLLQETMYMTVAI 196

  Fly   264 LDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILS 328
            :||||....|.:.:|||||..||:||:||||:||||:.:|.|:||.:||.:|:..||..:|::|:
Zfish   197 IDRFLQDHPVPKKQLQLVGVTAMFIASKYEEMYPPEIADFAFVTDRAYTTSQIREMEMKVLRVLN 261

  Fly   329 FDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSASVALARHILGM 393
            |....|....|:...:.:.|:..:...:..|..||::::.: .:.|.||.|:||:.||...:...
Zfish   262 FGFGRPLPLQFLRRASKIGDVTAEHHTLAKYFLELTMVDYD-MVHYPPSQMASAAYALTLKVFNC 325

  Fly   394 EMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNT-----QAMREKYNRDTYKKVAMMESVEM 453
            ..|||.|:....|..::|..|:.|:.   |....:|.     .|::.||:.....::|.:..::.
Zfish   326 GDWTPTLQHYMGYTEDELVPVMQHIA---KNVVRVNEGLSKHLAVKNKYSSQKQMRIATISQLKS 387

  Fly   454 S--KD 456
            |  ||
Zfish   388 SLIKD 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	58/125 (46%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	28/120 (23%)
ccnb1	NP_571588.1	Cyclin_N	140..262	CDD:278560	57/122 (47%)
ccnb1	NP_571588.1	Cyclin_C	267..385	CDD:281044	28/121 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.650