DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and CycB3

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	134/498 - (26%)
Similarity:	231/498 - (46%)	Gaps:	74/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NKENPGIKIPAGVKNTKQPL-AVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFRDVRNLN 75
            ::|..|:    |.|.|.|.| |::..|.::|     .:..|...:....|.:.||:  ..|.|.:
  Fly    95 DEEQSGV----GKKPTAQQLQALMDAKKQEN-----LSVNVFGASKMTTRASSKVE--DSVENCH 148

  Fly    76 -----VDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLASLVDKENHDVKFGAGQK 135
                 ::|.:.....:...||..::.....|     .....|:...:..|:...::   ..|.|.
  Fly   149 KVLDKLEEALARPKPRPKAVPAAKKTVLGEV-----QLPAMPNPMQIPVLLPPTHN---LAAPQV 205

  Fly   136 ELV--------DYDL--DSTPMS-VTDVQSPMSVDRSILGVIQ-----SSDISVGTETGVSP--- 181
            ..|        |::.  ||..|| :.||.|..|:..|  |..:     |:.:...||....|
  Fly   206 AAVKPVRRISNDFNKTEDSLYMSALEDVSSCDSMRLS--GNFEAARRRSAKLQQKTEQQPQPLLL 268

  Fly   182 ------TGRVKELPP------RNDRQRF---LEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDI 231
                  ..:|..:||      ..||:.:   .:|..|.|||..|.:..|.:. |...||.||..:
  Fly   269 TLPETAPSQVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEF-PIADYMPRQIHL 332

  Fly   232 SHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIY 296
            :..||::|:||:|||.|.::|:.|||||:|..:|.:|.:..:.:.||||:|.||.:||.||:|..
  Fly   333 TTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQ 397

  Fly   297 PPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYIS 361
            ||.:.:|:::.|.:|...:::|||:..|:::.:||..|.:|.|:..||....:|.....:..||.
  Fly   398 PPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYIL 462

  Fly   362 ELSLMEGETYLQYLPSLMSSASVALARHI------LGMEMWTPRLEEITTYKLEDLKTVVLHL-C 419
            |||||: ...:.:..|.|:||::.:|..:      |..:.||..|...|.|:|.|...:|..| .
  Fly   463 ELSLMD-YANISFSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNA 526

  Fly   420 HTHKTAKELNTQAMREKYNRDTYKKVA---MMESVEMSKDDFD 459
            ..|:..: ...:.:|.||:...:.:||   ::.:.|:.:.:.|
  Fly   527 GLHRKPR-ATIKTIRNKYSHKIFHEVAKVPLLTNQELFQGNLD 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	49/125 (39%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	34/125 (27%)
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	49/125 (39%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	34/121 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34088at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
	6	5.850