DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and ccnb1.2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_989121.1	Gene:	ccnb1.2 / 394726	XenbaseID:	XB-GENE-5736422	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	128/465 - (27%)
Similarity:	209/465 - (44%)	Gaps:	99/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MSNKENPGIKIPAGVKNTKQPLAVIGGK---AEKNALAPRANFAVLNGNNNVPRPAGK-----VQ 66
            |:|.||       .||.|      :.||   |.|..|.||.....:.....:..||.|     |:
Frog    10 MANAEN-------NVKTT------VAGKRVVATKPVLRPRTALGDIGNKAELKVPAKKELKPAVK 61

  Fly    67 VFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDN---NDTQVAPSGKSLASLVDKENHDV 128
            ..:.|:                  ||.:..:...|.|:|   ...||.||..|
Frog    62 AIKKVK------------------PVDKVLEPLKVREENVCPKPAQVEPSSPS------------ 96

  Fly   129 KFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTGRVKELPPRND 193
                             ||. |....|..:.::.      ||:.:          :||::...:|
Frog    97 -----------------PME-TSGCLPDELCQAF------SDVLI----------QVKDVDADDD 127

  Fly   194 RQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLY 258
            ....| ..:|..||..|.|..|.....:..|:..| :::.|||:|||||||:|..:::|..||::
Frog   128 GNPML-CSEYVKDIYCYLRSLENAQAVRQNYLHGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMF 190

  Fly   259 LSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVI 323
            ::|..:||||....|.:::|||||..||::||||||:||||:|:|.|:||.:|||||:..||..:
Frog   191 MTVGIIDRFLQDHPVPKNQLQLVGVTAMFLAAKYEEMYPPEIGDFTFVTDHTYTKAQIRDMEMKV 255

  Fly   324 LKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSASVALAR 388
            |::|.|.:..|....|:...:.:.::..:...:..|:.||.:::.: .:.|.||.:::|:..|:.
Frog   256 LRVLKFAIGRPLPLHFLRRASKIGEVTAEQHSLAKYLMELVMVDYD-MVHYSPSQIAAAASCLSL 319

  Fly   389 HILGMEMWTPRLEEITTYKLEDLKTVVLHLC-HTHKTAKELNTQ-AMREKYNRDTYKKVAMMES- 450
            .||....|||.:.....|..:||..|:.|:. :..|..|.|... .::.||......|::|:..
Frog   320 KILNTGEWTPTMHHYMAYFEDDLVPVMQHMAKNIIKVNKGLTKHLTVKNKYASSKQMKISMIPQL 384

  Fly   451 -----VEMSK 455
                 ||:::
Frog   385 RSDVVVELAR 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	59/125 (47%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	27/117 (23%)
ccnb1.2	NP_989121.1	COG5024	<120..381	CDD:227357	89/263 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010