DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and Ccna1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001011949.1	Gene:	Ccna1 / 295052	RGDID:	1310639	Length:	421	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	166/421 - (39%)
Similarity:	229/421 - (54%)	Gaps:	61/421 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RANFAVLNGNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQV 110
            |....||..|....|..|  |....:|..:..||| :.|....|:|            ||..::.
  Rat    37 RTVLGVLTENEQYRRACG--QEIATIRCFSGSENV-FPAAGKKVLP------------DNGVSEP 86

  Fly   111 APSGKSLASLVDKENHDVKFGAGQKELV---DYDLDSTPMSVTDVQ--------SPMSVDRSILG 164
            |..|..: .:.|.|..|.....|::.:|   .|::| |.|..:|:.        |||.||.:  .
  Rat    87 AKHGFDI-YMDDPEQGDRDSCPGREGIVFEDVYEVD-TSMLKSDLHFLLDFNTVSPMLVDST--A 147

  Fly   165 VIQSSDISVGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQK 229
            ..||.:   .|:.|                ...:.|.:|..:|..|.||:|.:||||..|||:|.
  Rat   148 HAQSEE---ATDFG----------------SDVINVTEYAEEIHRYLREAEVRHRPKAHYMRKQP 193

  Fly   230 DISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEE 294
            ||:..||:||:||||||.|||||.||||||:|.:||||||.|:|:|.|||||||||:.:|:||||
  Rat   194 DITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEE 258

  Fly   295 IYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTY---AVLCDMPEKLKYM 356
            ||||:|.|||::|||:|||.|:||||.::||:|:|||..||...|:..|   ..:|...|.|
  Rat   259 IYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENL--- 320

  Fly   357 TLYISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHT 421
            ..|::||||:|.:.:|:|||||:::|:..||.:|:....|...|...|.|.|.:   :|..|...
  Rat   321 AKYVAELSLLEADPFLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNE---IVPCLSEL 382

  Fly   422 HKTAKEL---NTQAMREKYNRDTYKKVAMME 449
            ||....:   ..||:||||....|..|::||
  Rat   383 HKACLSIPHRPQQAIREKYKASKYLHVSLME 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	84/125 (67%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	42/122 (34%)
Ccna1	NP_001011949.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Cyclin_N2	27..>101	CDD:406812	20/79 (25%)
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	93/182 (51%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	42/122 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I3438
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3191
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D520533at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm44887
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830