DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycA and cig2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_593889.1	Gene:	cig2 / 2543481	PomBaseID:	SPAPB2B4.03	Length:	411	Species:	Schizosaccharomyces pombe

Alignment Length:	502	Identity:	136/502 - (27%)
Similarity:	214/502 - (42%)	Gaps:	119/502 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASFQIHQDMSNKENPGIKIPAGVKNTKQPLAVIGGK------AEKNALAPRANFAVLNGNNNVP 59
            ||.:.|.:.:.:|.|         |::.|....:.||      .||..|:  .||.:     |:|
pombe     1 MALYSISKPVGSKIN---------KHSYQDENTLVGKQALSKGTEKTKLS--TNFEI-----NLP 49

  Fly    60 RPAGKVQVFRDVRNL---NVDENVEYGAKK----SNV-------VPVVEQF-KTFSVYEDNNDTQ 109
            |..    |..||.|:   |.||.....||:    ||:       .||..:| |...||..|.|..
pombe    50 RRT----VLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPS 110

  Fly   110 VAPSGKSLASLVDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVG 174
            |....|...|.||  :|               |.|.|
pombe   111 VETLQKDRVSNVD--DH---------------LSSNP---------------------------- 130

  Fly   175 TETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSIL 239
                                   |...:|..:|.||.|:.:.|..|.|.||.:||:::..||.||
pombe   131 -----------------------LMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREIL 172

  Fly   240 IDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFV 304
            .:||||:...:.|..|||||:|..:|||||:.:...||.||.|..|:.||:||||:..|.:..||
pombe   173 NEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFV 237

  Fly   305 FLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGE 369
            ::||.::|...|...|:.:|.:|:|||..|:...|:...:.......:.:.:..|::|:.|.:.:
pombe   238 YMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHD 302

  Fly   370 TYLQYLPSLMSSASVALARHILGMEMWTPRLEEIT-TYKLEDLKTVVLHLCHTHKTAKELNTQAM 433
             .|:|..|.:::|::.|:|.:|....|||:|.|.: .|:..:||.:...:.|.|.  |.|..:|.
pombe   303 -LLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHN--KPLEHKAF 364

  Fly   434 REKYNRDTYKKVAMM------ESVEMSKDDFDQLCEAYNCKQKEDEH 474
            .:||:...:.|.::.      :...:::.|.|.|....:.....|.|
pombe   365 FQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	55/125 (44%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	28/122 (23%)
cig2	NP_593889.1	COG5024	1..399	CDD:227357	133/488 (27%)
		Cyclin_N	139..265	CDD:278560	55/125 (44%)
		Cyclin_C	267..382	CDD:281044	28/117 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	123	1.000	Domainoid score	I1423
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	7	6.810