DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and cig1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_588110.2	Gene:	cig1 / 2539433	PomBaseID:	SPCC4E9.02	Length:	415	Species:	Schizosaccharomyces pombe

Alignment Length:	431	Identity:	105/431 - (24%)
Similarity:	186/431 - (43%)	Gaps:	91/431 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 FRDVRNLNVDENVEYGAKKSNV------------VPVVEQFKTFSVYEDNNDTQVAPSGKSLASL 120
            |:|...|..|.  .|..|||::            |..:.|....::.|.||::.::      :|.
pombe    13 FQDENQLQKDH--IYVKKKSHIKLNTGVRAPFKAVDNINQQDEPTLIEGNNESSIS------SST 69

  Fly   121 VDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTG-- 183
            .|....|..: ..:.|:.:..:.|||.|:.|..            :::.:.|.....|:...|
pombe    70 GDTFEEDFAY-QDKVEIEERSIRSTPKSIGDDD------------LENREGSFDAPEGILTHGKH 121

  Fly   184 RVKELP--PRNDRQRFLE--------------------VVQYQMDILEYFRESEKKHRPKPLYMR 226
            |:..:|  .:.|.....|                    |..|..:|..|.:..|:|..|.|.||.
pombe   122 RLPTIPEWTKEDLAALSEAAARLQANPSPEDIETDPSMVPDYDPEIFHYMQSLERKLAPPPNYMS 186

  Fly   227 RQKDISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAK 291
            .|::|....|.:|:||:|:|...::|..|||:|:|..:|||||...|...|:||||.:|:.||.|
pombe   187 VQQEIDWVTRHMLVDWIVQVQIHFRLLPETLFLAVNLIDRFLSIKVVSLQKVQLVGLSALLIACK 251

  Fly   292 YEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYM 356
            ||||:||.:..|..:....:|..:::|.|:.:|.:|.||:..|....|:...:........::.:
pombe   252 YEEIHPPSIYNFAHVVQGIFTVDEIIRAERYMLMLLDFDISWPGPMSFLRRISRADSYDHDIRML 316

  Fly   357 TLYISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHT 421
            ..|:.|::||: |.::....|.:::.:..|:..:||...|||                 .|:.::
pombe   317 AKYLQEVTLMD-EIFIGAHISFIAATAYYLSMQMLGHLDWTP-----------------CHVYYS 363

  Fly   422 HKTAKEL----------------NTQAMREKYNRDTYKKVA 446
            ..||::|                :..|:..||:.:..|:|:
pombe   364 GYTARQLKPCAIIIMECLVDAPNHHNAIYRKYSENRMKRVS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	51/125 (41%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	23/129 (18%)
cig1	NP_588110.2	COG5024	1..414	CDD:227357	105/431 (24%)
		Cyclin_N	166..292	CDD:278560	51/125 (41%)
		Cyclin_C	294..408	CDD:281044	23/129 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	123	1.000	Domainoid score	I1423
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
TreeFam	0	0.000	Not matched by this tool.
	6	5.710