DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and cya-1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_499018.1	Gene:	cya-1 / 176287	WormBaseID:	WBGene00000863	Length:	485	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	127/478 - (26%)
Similarity:	210/478 - (43%)	Gaps:	65/478 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MSNKENPGIKIPAGVKNTKQPL--AVIGGKAEKNALAPRANFAVLNGNNNVPR---PAGKV---- 65
            :|.|.:.|....:...|.|..:  |.:|||..:..           |.:|:.:   |:.|:
Worm     5 LSLKPSNGNAAKSQAVNNKNVIKNAPLGGKLTRQI-----------GTSNLLQQALPSKKIDESP 58

  Fly    66 ----------QVFRD--VRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNN---DTQVAPSGK 115
                      :||.|  ....|..|||:...|.|||:|.          ||||   :.:.....|
Worm    59 IIKIDAKDSFKVFEDQEPEKENSSENVDATEKDSNVIPA----------EDNNMIHELERKMEEK 113

  Fly   116 SLAS------LVDKENHDV--KFGAGQKE---LVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSS 169
            |.|.      :..::|.|:  :|.....|   |.|.| |...:||.......|| |:........
Worm   114 SRAEKLKFKFMQTRDNSDITSRFSEPPSEFSVLCDDD-DCDKVSVASSTFTTSV-RATFSSFHFD 176

  Fly   170 D----ISVGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKD 230
            :    ...|.|..|....:......|:|.....|  ::..||::|....:.|:|........|..
Worm   177 ENQRKKEFGKEEAVKKIQKKAAKEARDDSMFSSE--EFFPDIIKYMLHRQTKNRASHECFDIQSQ 239

  Fly   231 ISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEI 295
            ::..||:|||||..:|.:||....||.:|:|..:||.||...:.:.:.|||||.:|.||.|||||
Worm   240 VNEEMRTILIDWFSDVVKEYNFQKETFHLAVSLVDRALSMFNIDKMRFQLVGTTSMMIAVKYEEI 304

  Fly   296 YPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYI 360
            :|||:.:|..:||::|....:|.||:.:|....|.:..||:..|...:|...:..:|::....|:
Worm   305 FPPEIEDFALITDNTYRVPDILLMERFLLGKFDFVVAMPTSSWFGTCFAKRMNFTKKMRNTVHYL 369

  Fly   361 SELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTA 425
            .||||::.. :|:|.||.:::|:...|.....:|.|..::.:.|....||...|:..|...:..|
Worm   370 LELSLIDVH-FLRYRPSDIAAAACCFANLQADVESWPQKMVDDTGISTEDFVDVLRDLHRMYLNA 433

  Fly   426 KELNTQAMREKYNRDTYKKVAMM 448
            ...:.:::...|:.....:||::
Worm   434 STADFKSIFYNYSETAQMEVALL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	49/125 (39%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	27/115 (23%)
cya-1	NP_499018.1	Cyclin_N	215..338	CDD:278560	48/122 (39%)
cya-1	NP_499018.1	Cyclin_C	343..459	CDD:281044	27/115 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I3097
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto20005
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830