DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and Ccna2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_008759125.1	Gene:	Ccna2 / 114494	RGDID:	621059	Length:	445	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	166/453 - (36%)
Similarity:	243/453 - (53%)	Gaps:	75/453 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EKNALA--PRANFAVLNGNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFK---- 97
            ||.|.|  |||...:..|....|.|..:::..|.....::..|.|:       ||.|..:|
  Rat    25 EKVAPAQQPRAQAVLKAGKVRGPAPQQRLKTRRVAPLKDLPINDEH-------VPTVPSWKAVSK 82

  Fly    98 --TFSVYEDN-NDTQVAPSGKSLASLVDKENHDVKFGA------GQKELV--DYDLDST------ 145
              .|:::.|. .:||..|:.:......|.    :.|.|      .:|.||  ||.:|.:
  Rat    83 QPAFTIHVDEAEETQKRPAEQKETQCEDA----LAFSAAVSLPGARKPLVPLDYPMDGSFGQTHG 143

  Fly   146 ---------------PMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTGRVKELPPRNDRQ 195
                           .:...||:||.::|.||:                     :::..|.|..
  Rat   144 RQNSCYRQLCRCYDLTVETRDVESPHAMDISIV---------------------LEDEKPVNVN- 186

  Fly   196 RFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLYLS 260
               ||..|..||..|.||.|.|.:||..||:||.||:::||:||:||||||.|||||..|||:|:
  Rat   187 ---EVPDYHEDIHTYLREMEVKCKPKVSYMKRQPDITNSMRAILVDWLVEVGEEYKLQNETLHLA 248

  Fly   261 VFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILK 325
            |.|:|||||.|:|:|.||||||||||.:|:|:||||||||.|||::|||:|:|.||||||.::||
  Rat   249 VNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYSKKQVLRMEHLVLK 313

  Fly   326 ILSFDLCTPTAYVFINTYAV-LCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSASVALARH 389
            :|:|||..||...|:..|.: |.....|::.:.:::.||||::.:.||:|||||::.|:..||.:
  Rat   314 VLAFDLAAPTVNQFLTQYFLHLQPANCKVESLAMFLGELSLIDADPYLKYLPSLIAGAAFHLALY 378

  Fly   390 ILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQAMREKYNRDTYKKVAMMESVE 452
            .:..:.|...|.:.|.|.||.||..::.|..|:..|.:...|::||||....|..|:::...|
  Rat   379 TVTGQSWPESLVQKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKHSKYHSVSLLNPPE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	83/125 (66%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	38/116 (33%)
Ccna2	XP_008759125.1	Cyclin_N2	17..174	CDD:293109	36/159 (23%)
		Cyclin_N	194..320	CDD:278560	83/125 (66%)
		Cyclin_C	322..440	CDD:281044	38/117 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I3438
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55562
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3191
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D520533at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm44887
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830