DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and ccnb1

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_031753568.1	Gene:	ccnb1 / 100101736	XenbaseID:	XB-GENE-921525	Length:	392	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	123/404 - (30%)
Similarity:	187/404 - (46%)	Gaps:	59/404 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RDVRNLNVDENVEYG--AKKSNV-VPVVEQFKTFSVYEDNNDTQVAPSGKSLASL----VDKENH 126
            |.:| ||| ||||.|  .:|:.| .||:..........:.......|..::..:|    |:|
Frog     8 RSMR-LNV-ENVEPGMAGRKAAVSKPVLRPRNALGDIGNQISKAKVPLKRATKALRKPPVEK--- 67

  Fly   127 DVKFGAGQKELV--DYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTGRVKELP 189
                  .:|.:|  ||........|.|..:||                   ||.|..   ::|:|
Frog    68 ------SEKLIVPEDYVPKEAETPVPDSPNPM-------------------ETSVCV---IEEIP 104

  Fly   190 P-------------RNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILID 241
            |             ..|....:....|..||..|.|..|.|...:|.|:..| :|:.|||:||:|
Frog   105 PAFSSALIPIKDVDAEDSDNPMLCSDYVKDIYCYLRNMEVKQAIRPRYLDGQ-EINGNMRAILVD 168

  Fly   242 WLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFL 306
            |||:|...:||..||:.:::..|||||.:..|.:..|||.|.:||:||.||||||.|.:|:|.|:
Frog   169 WLVQVHLRFKLLQETMSMTIAILDRFLQENPVPKKLLQLAGVSAMFIACKYEEIYCPSIGDFAFV 233

  Fly   307 TDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETY 371
            ||.:|||:|:..||..||::|.||:..|....|:...:.:.::......:..|:.|| :|.....
Frog   234 TDHTYTKSQIRNMEMQILRVLKFDIGRPLPLHFLRRASKIGEVDSVHHTLAKYLIEL-VMTDYDM 297

  Fly   372 LQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQ--AMR 434
            :...||.:::|:..||..||....|||.||....||...|..|:.|:..........:|:  :::
Frog   298 VHVPPSQLAAAAFCLAMKILNSGEWTPVLEHYMAYKESSLMPVMQHIAKNIVKVNGGHTKFLSVK 362

  Fly   435 EKYNRDTYKKVAMM 448
            .||:.....||:.:
Frog   363 SKYSSSRQMKVSCL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	61/125 (49%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	28/117 (24%)
ccnb1	XP_031753568.1	CYCLIN_SF	128..256	CDD:424085	60/128 (47%)
ccnb1	XP_031753568.1	CYCLIN_SF	261..381	CDD:424085	28/117 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920