DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11597 and PPP3CC

DIOPT Version :9

Sequence 1:	NP_001036602.1	Gene:	CG11597 / 39337	FlyBaseID:	FBgn0036212	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001230903.1	Gene:	PPP3CC / 5533	HGNCID:	9316	Length:	521	Species:	Homo sapiens

Alignment Length:	295	Identity:	122/295 - (41%)
Similarity:	164/295 - (55%)	Gaps:	24/295 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGD 90
            ||..|:.:: :....:.:|..|..::.:.:|..|||||||||.||:.|.|:|||....|||||||
Human    51 RLEEEVALK-IINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGD 114

  Fly    91 LVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWRMCCRVF 155
            .||||..|:|..|.|.:||:.||..:.|||||||||..|..:.|.:||..:| |..|:..|...|
Human   115 YVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY-SEQVYDACMETF 178

  Fly   156 DLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAPG------- 213
            |.|||||:::...||||||:||::..|||:|.|||..|.|..|.:.|||||||.|..|
Human   179 DCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEH 243

  Fly   214 -WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWH-------FGQLLVTIWSAPNY 270
             ...:.||....:....|.||.:.|.:..|.|||:....|:|.:       |.. |:||:|||||
Human   244 YTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPS-LITIFSAPNY 307

  Fly   271 CYRCGNKAAILRLNAAGDYDFKVFEAQALHSKPQP 305
            .....||||:|:      |:..|...:..:..|.|
Human   308 LDVYNNKAAVLK------YENNVMNIRQFNCSPHP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11597	NP_001036602.1	PTZ00239	12..307	CDD:173488	122/295 (41%)
CG11597	NP_001036602.1	MPP_superfamily	12..296	CDD:301300	120/284 (42%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	122/295 (41%)
		Catalytic. /evidence=ECO:0000305	52..343		121/294 (41%)
		PP2Ac	54..325	CDD:197547	117/279 (42%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820