DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11597 and PPP3CB

DIOPT Version :9

Sequence 1:	NP_001036602.1	Gene:	CG11597 / 39337	FlyBaseID:	FBgn0036212	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001135825.1	Gene:	PPP3CB / 5532	HGNCID:	9315	Length:	525	Species:	Homo sapiens

Alignment Length:	321	Identity:	130/321 - (40%)
Similarity:	177/321 - (55%)	Gaps:	29/321 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LCPEAMNDADRL--VENLRHVPV---RLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIH 64
            |..|.:.|.|.:  |:.|::..|   |:..|:.:| :....:.:|..|..::.:::|..||||||
Human    38 LTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALR-IINEGAAILRREKTMIEVEAPITVCGDIH 101

  Fly    65 GQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSAT 129
            |||.||:.|.|:|||....|||||||.||||..|:|..|.|..||:.:|:.:.|||||||||..|
Human   102 GQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT 166

  Fly   130 RSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEI 194
            ..:.|.:||..:| |..|:..|...||.|||||:::...|||||||||::..|||:|.|||..|.
Human   167 EYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEP 230

  Fly   195 PESGIIADLLWSDPQEAPGWAASP--------RGHGKLFGGDVVEEFTRANGISLICRAHQLAQD 251
            |..|.:.|||||||.|..|...|.        ||....:....|.||.:.|.:..|.|||:....
Human   231 PAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDA 295

  Fly   252 GFRWH-------FGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQALHSKPQP 305
            |:|.:       |.. |:||:|||||.....||||:|:      |:..|...:..:..|.|
Human   296 GYRMYRKSQTTGFPS-LITIFSAPNYLDVYNNKAAVLK------YENNVMNIRQFNCSPHP 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11597	NP_001036602.1	PTZ00239	12..307	CDD:173488	128/314 (41%)
CG11597	NP_001036602.1	MPP_superfamily	12..296	CDD:301300	126/303 (42%)
PPP3CB	NP_001135825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MPP_PP2B	50..354	CDD:277361	126/309 (41%)
		Catalytic. /evidence=ECO:0000305	65..356		122/294 (41%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	316..320		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	357..379
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	402..416
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	417..424
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820