DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11597 and PPEF1

DIOPT Version :9

Sequence 1:	NP_001036602.1	Gene:	CG11597 / 39337	FlyBaseID:	FBgn0036212	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001364915.1	Gene:	PPEF1 / 5475	HGNCID:	9243	Length:	653	Species:	Homo sapiens

Alignment Length:	335	Identity:	91/335 - (27%)
Similarity:	147/335 - (43%)	Gaps:	67/335 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PEAMNDADRLVE-----NLRHVPVRLPRELEVRQLCRSLSDLLVGESNLLSLQSPQI-VCGDIHG 65
            |....|.|.|:|     .:.|....|....|.:::.:.:.:.    :::.:..|.:: :|||:||
Human   115 PLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNF----THIQTSPSKEVTICGDLHG 175

  Fly    66 QFEDLLHLLELGGSVQEHR-YLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSAT 129
            :.:||..:....|...|.. |:|.||.|||||||:|..::|....:.:|..:.|.|||||.....
Human   176 KLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMN 240

  Fly   130 RSYGFYEECLSRY--GSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCH 192
            ..|||.:|.|.:|  ....:.::....:..||:..|:|..||.:|||:|    ...||..|.|..
Human   241 LRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGIS----ETTDLNLLHRVE 301

  Fly   193 E-------IPES---------------GI-------------------------IADLLWSDPQE 210
            .       ||.:               |:                         |.|:|||||:.
Human   302 RNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRG 366

  Fly   211 APG-WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFR-WHFGQLLVTIWSAPNYCYR 273
            ..| :..:.||.|..||.||..:......:.::.|:|:...:|:. .|.|: :|||:||.||...
Human   367 KNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK-VVTIFSASNYYEE 430

  Fly   274 CGNKAAILRL 283
            ..|:.|.::|
Human   431 GSNRGAYIKL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11597	NP_001036602.1	PTZ00239	12..307	CDD:173488	90/330 (27%)
CG11597	NP_001036602.1	MPP_superfamily	12..296	CDD:301300	90/330 (27%)
PPEF1	NP_001364915.1	IQ	18..37	CDD:197470
		MPP_RdgC	115..452	CDD:277364	91/335 (27%)
		Catalytic	121..455		89/329 (27%)
		EF-hand_7	568..636	CDD:404394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810