DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11597 and Ppp3ca

DIOPT Version :9

Sequence 1:	NP_001036602.1	Gene:	CG11597 / 39337	FlyBaseID:	FBgn0036212	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_058737.1	Gene:	Ppp3ca / 24674	RGDID:	3382	Length:	521	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	130/313 - (41%)
Similarity:	172/313 - (54%)	Gaps:	27/313 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NDADRLVENLR-HV--PVRLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLH 72
            ||....|:.|: |:  ..||...:.:|.:....| :|..|.|||.:.:|..|||||||||.||:.
  Rat    37 NDGKPRVDILKAHLMKEGRLEESVALRIITEGAS-ILRQEKNLLDIDAPVTVCGDIHGQFFDLMK 100

  Fly    73 LLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEE 137
            |.|:|||....|||||||.||||..|:|..|.|.|||:.:|..:.|||||||||..|..:.|.:|
  Rat   101 LFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQE 165

  Fly   138 CLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIAD 202
            |..:| |..|:..|...||.|||||:::...|||||||||::..|||:|.|||..|.|..|.:.|
  Rat   166 CKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCD 229

  Fly   203 LLWSDPQEAPGWAASP--------RGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWH--- 256
            :|||||.|..|...:.        ||....:....|.:|.:.|.:..|.|||:....|:|.:
  Rat   230 ILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKS 294

  Fly   257 ----FGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQALHSKPQP 305
                |.. |:||:|||||.....||||:|:      |:..|...:..:..|.|
  Rat   295 QTTGFPS-LITIFSAPNYLDVYNNKAAVLK------YENNVMNIRQFNCSPHP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11597	NP_001036602.1	PTZ00239	12..307	CDD:173488	129/312 (41%)
CG11597	NP_001036602.1	MPP_superfamily	12..296	CDD:301300	127/301 (42%)
Ppp3ca	NP_058737.1	MPP_PP2B	41..345	CDD:277361	128/309 (41%)
		Catalytic. /evidence=ECO:0000305	56..340		123/292 (42%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250\|UniProtKB:Q08209	327..336		1/8 (13%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:Q08209	341..369		130/313 (42%)
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:Q08209	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:1322410	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820