DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and CBR1

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_012221.2	Gene:	CBR1 / 854768	SGDID:	S000001305	Length:	284	Species:	Saccharomyces cerevisiae

Alignment Length:	298	Identity:	101/298 - (33%)
Similarity:	150/298 - (50%)	Gaps:	52/298 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDTRRFRFGL 78
            |.|:.::...|:..:::..| |||..:|.|          ||....||:||..|:|:|..::|||
Yeast     9 VVVIVIVVVPLLFKFIIGPK-TKPVLDPKR----------NDFQSFPLVEKTILTHNTSMYKFGL 62

  Fly    79 PSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDV-GYVDLVVKVYFKDSHPKFPAGGKMT 142
            |....|||||:||||.:.|.|:.:.|.|.|||.|.|.|. |..:|:||.|        |. |.::
Yeast    63 PHADDVLGLPIGQHIVIKANINGKDITRSYTPTSLDGDTKGNFELLVKSY--------PT-GNVS 118

  Fly   143 QHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPMLQLARE 207
            :.:.:|::||.|..:||.|...|..|                ....:.||||||||.||.|:.:
Yeast   119 KMIGELKIGDSIQIKGPRGNYHYERN----------------CRSHLGMIAGGTGIAPMYQIMK- 166

  Fly   208 VLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKRMPRMGNARF 272
            .:.....|.|:::|:|.|..|:||||:.||:.|....|.||||.|.:|..:..
Yeast   167 AIAMDPHDTTKVSLVFGNVHEEDILLKKELEALVAMKPSQFKIVYYLDSPDRE------------ 219

  Fly   273 VAWSYNTGHVNDDMMQQHLYPPGEDTL-CLLCGPPPMV 309
             .|:...|::..|::::||.....|.: .|:||||.||
Yeast   220 -DWTGGVGYITKDVIKEHLPAATMDNVQILICGPPAMV 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	92/261 (35%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	90/253 (36%)
CBR1	NP_012221.2	cyt_b5_reduct_like	43..284	CDD:99780	90/253 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I2007
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6182
Inparanoid	1	1.050	151	1.000	Inparanoid score	I1116
Isobase	1	0.950	-	0	Normalized mean entropy	S798
OMA	1	1.010	-	-		QHG54129
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm46942
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
TreeFam	1	0.960	-	-
	14	13.710