DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and cyb5r2

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001038825.1	Gene:	cyb5r2 / 751641	ZFINID:	ZDB-GENE-060825-83	Length:	309	Species:	Danio rerio

Alignment Length:	324	Identity:	160/324 - (49%)
Similarity:	217/324 - (66%)	Gaps:	25/324 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLAVGVVAVLAGALIVHYLLNK----KSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDT 71
            |:.:||..|:   :.|.||..|    .||.|:.: |:..  :.|.||:.||.|||||||.::|||
Zfish     7 PVLIGVSIVV---ITVLYLFLKPAGSNSTPPKPQ-NKIP--KALQDPSVKYPLPLIEKEEINHDT 65

  Fly    72 RRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHPKFP 136
            :||||||||..||||||:||||:|.|.::..|::|.|||:|||:|.||||||||||:|::||.:|
Zfish    66 KRFRFGLPSSSHVLGLPIGQHIYLSAKVNGSLVVRAYTPVSSDQDQGYVDLVVKVYYKNTHPSYP 130

  Fly   137 AGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPM 201
            .||||:|:|:.:::||.|.||||:|.|.|.|.|.|:|:..:|...:....|.|.|||||||||||
Zfish   131 DGGKMSQYLDNMKIGDTIDFRGPNGLLVYNGKGKFAIRPDKKSEAEVRKFKHVAMIAGGTGITPM 195

  Fly   202 LQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKRMPR 266
            |||.|.:...| .|:|..:|:||||:|||||||.||||:.:.||.:.|:|||:|:.:|
Zfish   196 LQLVRSITADS-SDETVCSLIFANQTEKDILLRNELDEVHRNHPSKLKLWYTLDRPSE------- 252

  Fly   267 MGNARFVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAEQRFSY 330
                   .|.|:.|.||..||:.||.|...|.|.::||||.|:...|:|.|.:||::.|..|:|
Zfish   253 -------GWKYSEGFVNAAMMKDHLPPADSDVLVVMCGPPAMIEKACLPNLLKLGYKKENIFAY 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	146/278 (53%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	142/270 (53%)
cyb5r2	NP_001038825.1	PTZ00319	9..309	CDD:173521	158/320 (49%)
cyb5r2	NP_001038825.1	cyt_b5_reduct_like	53..309	CDD:99780	142/270 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596129
Domainoid	1	1.000	163	1.000	Domainoid score	I3917
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6182
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2336
OMA	1	1.010	-	-		QHG54129
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm25221
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	1	1.100	-	-	LDO	PTHR19370
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800