DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and Cyb5r1

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_082333.1	Gene:	Cyb5r1 / 72017	MGIID:	1919267	Length:	305	Species:	Mus musculus

Alignment Length:	319	Identity:	163/319 - (51%)
Similarity:	223/319 - (69%)	Gaps:	26/319 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDTRRFRF 76
            |.||::.:| |..:..||: ::|.:|:         .||.||::||||.|::|..:||:||||||
Mouse    13 LGVGLLTLL-GLALGTYLV-RRSRRPQ---------VTLQDPDEKYLLRLLDKTTVSHNTRRFRF 66

  Fly    77 GLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHPKFPAGGKM 141
            .||:..|:||||||:|::|.|.||..|:||||||::||||.||||||:|||.|..|||||.||||
Mouse    67 ALPTAHHILGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKM 131

  Fly   142 TQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPMLQLAR 206
            :|:|:.|::||.:.||||||.|.|.|.|.|:|:..:|.||:...||::.||||||||||||||.|
Mouse   132 SQYLDSLKIGDMVEFRGPSGLLSYAGKGNFNIQPNKKSPPELRVAKKLGMIAGGTGITPMLQLIR 196

  Fly   207 EVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKRMPRMGNAR 271
            .:|| ..:|.|:..||||||:|:||:||.:|:||..::|::||:|:|:|...|
Mouse   197 AILK-VPEDPTQCFLLFANQTERDIILREDLEELQAQYPNRFKLWFTLDSPPE------------ 248

  Fly   272 FVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAEQRFSY 330
              .|:|:.|.|..||:|:||..|.||.|.|||||||||...|.|.|::||:..:.||:|
Mouse   249 --DWTYSKGFVTADMIQEHLPAPAEDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	151/278 (54%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	146/270 (54%)
Cyb5r1	NP_082333.1	PTZ00319	33..305	CDD:173521	155/295 (53%)
Cyb5r1	NP_082333.1	cyt_b5_reduct_like	49..305	CDD:99780	146/270 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4982
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2396
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54129
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm44164
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800