DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and cyb5r2

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	XP_012816675.1	Gene:	cyb5r2 / 595026	XenbaseID:	XB-GENE-1006041	Length:	306	Species:	Xenopus tropicalis

Alignment Length:	330	Identity:	160/330 - (48%)
Similarity:	227/330 - (68%)	Gaps:	26/330 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARIVESNFVPLAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKE 65
            ::.:.:||.: :|:.|:    |..::.:|:....::.::.|      .||:|||.||.||||||:
Frog     3 ISTVSDSNML-VALAVI----GVTVLLFLIKALGSQAKKAP------LTLLDPNAKYPLPLIEKQ 56

  Fly    66 NLSHDTRRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKD 130
            .:||||::|||||||::||||||||||::|.|.|:..|::|.|||:||||..|:|||:||||:|:
Frog    57 EISHDTKKFRFGLPSQEHVLGLPVGQHVYLSAKINGSLVVRAYTPVSSDEVKGHVDLIVKVYYKN 121

  Fly   131 SHPKFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGG 195
            .|||||.||||:|||:.|::|:.|.||||:|.|.|...|.|:|:..:|..||...||.|.|:|||
Frog   122 VHPKFPEGGKMSQHLDSLKIGETIDFRGPNGLLVYKEKGKFAIRPDKKSEPKLKVAKHVGMLAGG 186

  Fly   196 TGITPMLQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEA 260
            |||||||||.|:: .:...|.|:.:|:||||:|.|||||.||:.:|:.||:|||:|||:|:
Frog   187 TGITPMLQLIRQI-TQDPNDNTKCSLIFANQTEDDILLRYELETVAKSHPEQFKLWYTLDR---- 246

  Fly   261 IKRMPRMGNARFVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAE 325
                |..|      |.|..|.|..||:::||.||.||.:.|:||||||:.:.|...|.:||:...
Frog   247 ----PPQG------WKYGAGFVTADMIKEHLPPPSEDVVVLMCGPPPMIQFACQDNLTKLGYPEA 301

  Fly   326 QRFSY 330
            .||:|
Frog   302 GRFAY 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	150/278 (54%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	145/270 (54%)
cyb5r2	XP_012816675.1	PTZ00319	11..298	CDD:173521	154/312 (49%)
cyb5r2	XP_012816675.1	cyt_b5_reduct_like	50..306	CDD:99780	145/270 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4034
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6182
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2425
OMA	1	1.010	-	-		QHG54129
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm49339
Panther	1	1.100	-	-	LDO	PTHR19370
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110