DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and CYB5R1

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_057327.2	Gene:	CYB5R1 / 51706	HGNCID:	13397	Length:	305	Species:	Homo sapiens

Alignment Length:	319	Identity:	164/319 - (51%)
Similarity:	224/319 - (70%)	Gaps:	26/319 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDTRRFRF 76
            |.||:|.:| |..:..||: ::|.:|:         .||:|||:||||.|::|..:||:|:||||
Human    13 LGVGLVTLL-GLAVGSYLV-RRSRRPQ---------VTLLDPNEKYLLRLLDKTTVSHNTKRFRF 66

  Fly    77 GLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHPKFPAGGKM 141
            .||:..|.||||||:||:|...||..|:||||||::||||.||||||:|||.|..|||||.||||
Human    67 ALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKM 131

  Fly   142 TQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPMLQLAR 206
            :|:|:.|::||.:.||||||.|.|.|.|.|:|:..:|.||:...||::.||||||||||||||.|
Human   132 SQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIR 196

  Fly   207 EVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKRMPRMGNAR 271
            .:|| ..:|.|:..||||||:||||:||.:|:||..::|::||:|:|:|       ..|:
Human   197 AILK-VPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLD-------HPPK----- 248

  Fly   272 FVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAEQRFSY 330
              .|:|:.|.|..||:::||..||:|.|.|||||||||...|.|.|::||:..:.||:|
Human   249 --DWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	151/278 (54%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	145/270 (54%)
CYB5R1	NP_057327.2	PLN02252	<38..300	CDD:215141	151/276 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3780
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2404
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54129
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm42109
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810