DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and CYB5R4

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_057314.2	Gene:	CYB5R4 / 51167	HGNCID:	20147	Length:	521	Species:	Homo sapiens

Alignment Length:	331	Identity:	89/331 - (26%)
Similarity:	145/331 - (43%)	Gaps:	91/331 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIVESNFVPLAVGVVAVL-------AGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLP 60
            |:|||      ||.:.::       :...:.|.|.|..|..||::.....|           ...
Human   232 RVVES------VGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYR-----------KCQ 279

  Fly    61 LIEKENLSHDTRRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSD------EDV-- 117
            ||.||:::||||.|...||...| |.:|:|||::|...|....|::||||:|..      |.|
Human   280 LISKEDVTHDTRLFCLMLPPSTH-LQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLP 343

  Fly   118 --GYVDLVVKVYFKDSHPKFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDP 180
              .|:..::|:|        |. |..|..|::|::||.:|...|        .|.|.|.|.::
Human   344 NNKYIYFLIKIY--------PT-GLFTPELDRLQIGDFVSVSSP--------EGNFKISKFQE-- 389

  Fly   181 PKHVTAKRVNMIAGGTGITPMLQLAREVLKRSD-KDKTELALLFANQSEKDILLRAELDELAQKH 244
                 .:.:.::|.|||.|||:::....|  :| ....::.|:|.|::|.||:.|::|::||.|.
Human   390 -----LEDLFLLAAGTGFTPMVKILNYAL--TDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKD 447

  Fly   245 PDQFKIWYTVDKANEAIKRMPRMGNARFV------AWSYNTGHVNDDMMQQHLYP--PGEDTLCL 301
                             ||:    :..||      .|:...||::..::.:.|..  .....|..
Human   448 -----------------KRL----DVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVC 491

  Fly   302 LCGPPP 307
            :|||.|
Human   492 ICGPVP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	76/276 (28%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	76/268 (28%)
CYB5R4	NP_057314.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Cyt-b5	58..130	CDD:306642
		p23_NCB5OR	170..256	CDD:107240	6/29 (21%)
		cyt_b5_reduct_like	278..519	CDD:99780	76/268 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820