DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and T05H4.4

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_504639.1	Gene:	T05H4.4 / 188150	WormBaseID:	WBGene00020267	Length:	303	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	164/322 - (50%)
Similarity:	229/322 - (71%)	Gaps:	24/322 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVESNFVPLAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLS 68
            :||:|.:.:..|||.:.:.:|.: ||...::.|..:        |||.|.:.|||||||||..:|
Worm     1 MVENNTLAITGGVVLISSVSLFL-YLRQLRAEKKSK--------RTLEDDSVKYLLPLIEKFEIS 56

  Fly    69 HDTRRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHP 133
            |:||:||||||||.|:||||:|.|::|.|.|..:||:|.|||:|.|.|:|||||:||||||::|.
Worm    57 HNTRKFRFGLPSKDHILGLPIGHHVYLSANIGGKLIVRSYTPVSCDLDLGYVDLMVKVYFKNTHE 121

  Fly   134 KFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGI 198
            :||.||||:||||.|::||.:|||||.|.:.|.|:|.|:::..:|..||:...|.::||||||||
Worm   122 RFPDGGKMSQHLESLKIGDTVSFRGPHGSIIYKGSGLFTVRMDKKAEPKNRFFKHLSMIAGGTGI 186

  Fly   199 TPMLQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEAIKR 263
            |||||:...:| |...|.|::.||||||:|.|||.|.||||||:|||.:|::||||.||::
Worm   187 TPMLQVIAAIL-RDPIDATQIRLLFANQTEDDILCRKELDELAEKHPTRFRVWYTVSKASK---- 246

  Fly   264 MPRMGNARFVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERLGHRAE 325
                      .|.|:|||:|::|:::||:|..|::..||||||.|:|..|||.|::|||.:|
Worm   247 ----------DWRYSTGHINEEMIKEHLFPSNEESAVLLCGPPAMINCACIPNLDKLGHNSE 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	151/275 (55%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	147/267 (55%)
T05H4.4	NP_504639.1	PTZ00319	11..303	CDD:173521	161/312 (52%)
T05H4.4	NP_504639.1	cyt_b5_reduct_like	47..303	CDD:99780	147/267 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167395
Domainoid	1	1.000	167	1.000	Domainoid score	I2333
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6182
Inparanoid	1	1.050	347	1.000	Inparanoid score	I1361
Isobase	1	0.950	-	0	Normalized mean entropy	S798
OMA	1	1.010	-	-		QHG54129
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm14161
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	1	1.100	-	-	O	PTHR19370
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750