DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5946 and hpo-19

DIOPT Version :9

Sequence 1:	NP_001287035.1	Gene:	CG5946 / 39336	FlyBaseID:	FBgn0036211	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_504638.1	Gene:	hpo-19 / 179029	WormBaseID:	WBGene00020268	Length:	309	Species:	Caenorhabditis elegans

Alignment Length:	335	Identity:	175/335 - (52%)
Similarity:	237/335 - (70%)	Gaps:	34/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVESNFVPLAVGVVAVLAGALIVH--------YLLNKKSTKPRREPNRTARLRTLVDPNDKYLLP 60
            :||:|.:.:..|||.|.:.|:.::        :.|.|||.|           |||||.:.||.||
Worm     1 MVENNTLIITGGVVVVSSIAIYIYLKATNTCPFSLCKKSKK-----------RTLVDDSVKYPLP 54

  Fly    61 LIEKENLSHDTRRFRFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVK 125
            ||||..:|||||:||||||||.|:||||:|||::|.|.||.::|:|||||:|||||:|:|||:||
Worm    55 LIEKFEISHDTRKFRFGLPSKDHILGLPIGQHVYLTANIDGKIIVRPYTPVSSDEDLGFVDLMVK 119

  Fly   126 VYFKDSHPKFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVN 190
            ||||:::.|||.||||:||||.|::||.|:||||.|.:.|.|:|.||||..:|..||:...|.::
Worm   120 VYFKNTNEKFPEGGKMSQHLESLKIGDTINFRGPQGNIVYKGHGLFSIKADKKAEPKNRVFKHLS 184

  Fly   191 MIAGGTGITPMLQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVD 255
            |||||||||||||:...:| |...|.|::.||||||:|.|||.|.|||:||::||.:|::|||||
Worm   185 MIAGGTGITPMLQVIAAIL-RDPTDTTQIRLLFANQTEDDILCRQELDDLAKEHPTRFRVWYTVD 248

  Fly   256 KANEAIKRMPRMGNARFVAWSYNTGHVNDDMMQQHLYPPGEDTLCLLCGPPPMVNYTCIPGLERL 320
                   |.|       |.|||::|.:||.|::::|:|||:|:..||||||||:|:.|||.||:|
Worm   249 -------RPP-------VMWSYSSGFINDSMIKENLFPPGDDSAVLLCGPPPMINFACIPNLEKL 299

  Fly   321 GHRAEQRFSY 330
            .:....|..:
Worm   300 EYDPANRLLF 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5946	NP_001287035.1	PTZ00319	51..330	CDD:173521	159/278 (57%)
CG5946	NP_001287035.1	cyt_b5_reduct_like	59..330	CDD:99780	155/270 (57%)
hpo-19	NP_504638.1	PTZ00319	9..309	CDD:173521	172/325 (53%)
hpo-19	NP_504638.1	cyt_b5_reduct_like	53..309	CDD:99780	155/270 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167394
Domainoid	1	1.000	167	1.000	Domainoid score	I2333
eggNOG	1	0.900	-	-		E1_COG0543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6182
Inparanoid	1	1.050	347	1.000	Inparanoid score	I1361
Isobase	1	0.950	-	0	Normalized mean entropy	S798
OMA	1	1.010	-	-		QHG54129
OrthoDB	1	1.010	-	-		D1311668at2759
OrthoFinder	1	1.000	-	-		FOG0000472
OrthoInspector	1	1.000	-	-		otm14161
orthoMCL	1	0.900	-	-		OOG6_100179
Panther	1	1.100	-	-	LDO	PTHR19370
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2205
SonicParanoid	1	1.000	-	-		X606
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790