DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14130 and ALKBH2

DIOPT Version :9

Sequence 1:	NP_648511.2	Gene:	CG14130 / 39335	FlyBaseID:	FBgn0036210	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_001001655.1	Gene:	ALKBH2 / 121642	HGNCID:	32487	Length:	261	Species:	Homo sapiens

Alignment Length:	248	Identity:	49/248 - (19%)
Similarity:	86/248 - (34%)	Gaps:	85/248 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VESNAIKANLTAYFGKWPETEQKEFRQHMRIITDFISEPEE--QQLHEEIEPY---MSRLRYEFD 81
            :.:..:..:.|..|||                    :|.:|  |:|.:|:|.:   ::|::. |.
Human    60 IRAEGLDCSYTVLFGK--------------------AEADEIFQELEKEVEYFTGALARVQV-FG 103

  Fly    82 HW----------DDAIHGFRET------ERKKWFPKNREILERVRQ--VAFDGAVMPYVHILDLA 128
            .|          .||  |...|      ..|.|.|    :|||:|.  ....|....:| :::..
Human   104 KWHSVPRKQATYGDA--GLTYTFSGLTLSPKPWIP----VLERIRDHVSGVTGQTFNFV-LINRY 161

  Fly   129 PDGVIKPHVDSTRYCGNTISGISLLSDSVMRLVRTDEQRYQQQSSGTATDPNSQGSEPDAAYRHQ 193
            .||.  .|:...|                      |::|  :.:.|:.....|.|:..|..:||:
Human   162 KDGC--DHIGEHR----------------------DDER--ELAPGSPIASVSFGACRDFVFRHK 200

  Fly   194 -PEASLKNNFYADILLP--RRSLYIMSHTARYKFTHEILAKEHSQFQGALVPR 243
             ......:...|.:.||  ..||.:|:|.....:.|.:..::.     .|.||
Human   201 DSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKK-----VLAPR 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14130	NP_648511.2	None
ALKBH2	NP_001001655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		2OG-FeII_Oxy_2	72..254	CDD:316090	48/236 (20%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18432238	102..104		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18432238	122..124		0/1 (0%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000269\|PubMed:18432238	159..161		0/1 (0%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000269\|PubMed:18432238	248..254		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900