DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fgfrl1a and btl

DIOPT Version :9

Sequence 1:	NP_956670.1	Gene:	fgfrl1a / 393347	ZFINID:	ZDB-GENE-040128-2	Length:	483	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	113/443 - (25%)
Similarity:	167/443 - (37%)	Gaps:	101/443 - (22%)

- Green bases have known domain annotations that are detailed below.

Zfish    18 DCARGPPRVAEKIAHRQTV-------------RIGRTMKLQCPVEGDP-PPLIMWTKDGR--NIH 66
            ||.|..|...|.|:.:.||             .:|..:.::|.:|... .|.|.|...|.  ||.
  Fly   221 DCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNID 285

Zfish    67 SGWMRFRVLQ----------------QALRIKEVEADDAGTFICKATNGFG-------------- 101
            ....|.|...                |.||:..|..:|.|.:||.|.|..|
  Fly   286 DLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPS 350

Zfish   102 ---SVNINYTLIV---IDDSSAGREG----ARPAGETEYSTDLTGKLVRPRFTQPAKMRKRVIAR 156
               :|....|..|   |..:|.|.:.    ..||.|.      :|.:..|.|.:..|..:..::
  Fly   351 DTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEA------SGGVGPPVFRKELKRLQHSLS- 408

Zfish   157 PVGSSVRLKCTASGNPRPDIVWLKDSRPLTPEEVGEGRKKKWTLSLKNLTPEHSGKYTCHVSNRA 221
              |::|.|.|...|  :.:|.|.||.:||. .|:|...:|.|||.....|.|.||.|.|.|.|..
  Fly   409 --GNTVNLACPVYG--KANITWTKDKKPLN-RELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAW 468

Zfish   222 GEINATYKVEVIQRTNSKPILTGTHPVNTTVDYGGTTSFQCKVRSDVKPVIQWLKRVEPGGEGKY 286
            |.|...:.|::..||.|.||:  ..|.|.||...|:...:|.|.||:.|.:.|.:.|........
  Fly   469 GCIQFDFSVQINDRTRSAPII--VVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDG 531

Zfish   287 NSTIEVGDHHFVVLPTGDVWSRPDGSYLNKLLITRAKEEDAGMYICLGANTMGYSFRSAFLTVLP 351
            ..::|:.:.:|.|.....|           |.:.....:..|.|.||.::.:|.|..|.:|.|:
  Fly   532 LKSVEIQNLNFTVTNDSVV-----------LTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVV- 584

Zfish   352 DPKPPFSPIPSVLPPSLPWPVIIGIPAGI---------VFILGTVLLWFCQSR 395
                      |.|||...:.::...|.|.         :|:||:..:.|...|
  Fly   585 ----------SPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fgfrl1a	NP_956670.1	I-set	32..111	CDD:254352	26/127 (20%)
		IGc2	38..101	CDD:197706	21/81 (26%)
		I-set	141..232	CDD:254352	31/90 (34%)
		Ig2_FGFRL1-like	151..232	CDD:143264	28/80 (35%)
		I-set	245..349	CDD:254352	25/103 (24%)
		Ig	255..350	CDD:299845	21/94 (22%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	4/10 (40%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	21/88 (24%)
		Ig	258..340	CDD:143165	21/81 (26%)
		I-set	394..479	CDD:254352	31/90 (34%)
		IGc2	408..469	CDD:197706	25/66 (38%)
		IG_like	492..583	CDD:214653	25/101 (25%)
		Ig	507..583	CDD:299845	20/86 (23%)
		PKc_like	700..1000	CDD:304357
		TyrKc	712..996	CDD:197581
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810