DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and NRP1

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:XP_006717584.1 Gene:NRP1 / 8829 HGNCID:8004 Length:924 Species:Homo sapiens


Alignment Length:1003 Identity:196/1003 - (19%)
Similarity:338/1003 - (33%) Gaps:265/1003 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2208 NECNGEIQLNQQAPNYTIMSPGYPYLPHPHAECTWLVMAP-PGETIAVDFDEQFELSARHCDKEN 2271
            ::|...|::  ::|.| :.|||||:..||..:|.||:.|| |.:.|.::|:..|:|..|.|..:.
Human    25 DKCGDTIKI--ESPGY-LTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

  Fly  2272 VEFFDGATKLARLLLRTCRK--PQNTVRTTGNLLLVHYQSQLNEPTGGFRLNLSL----STCGGQ 2330
            ||.|||..:......:.|.|  |...| ::|..|.:.:.|.......||.:...:    ..|...
Human    87 VEVFDGENENGHFRGKFCGKIAPPPVV-SSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQN 150

  Fly  2331 FSASAGFISSENYPHLGGYPKPSVCEYSILLPKNAFIRLNITDLHLPYDANGTSS-----DRLEI 2390
            ::..:|.|.|..:|.  .||....|.|.:.:||.:.|.|......|..|:|....     |||||
Human   151 YTTPSGVIKSPGFPE--KYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEI 213

  Fly  2391 VD-YEDRTQKL-----MVLDGRTKTS---ILFTLNTNAATIRFVAVQNVNNYRGFKIRYERYVGT 2446
            .| :.|....:     ....||.::|   :.....|::|..:          .||...|.....:
Human   214 WDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAK----------EGFSANYSVLQSS 268

  Fly  2447 CSRDINGASGDIVIPPMPQSVWLRFCRLRISVPKGQRVRLNLLNLSNIRVVKRNDTNRSFMQIGR 2511
            .|.|..                   |...:.:..|:      ::...|....:..||.| .:..|
Human   269 VSEDFK-------------------CMEALGMESGE------IHSDQITASSQYSTNWS-AERSR 307

  Fly  2512 LESMAHFSFYNDANSLSKIAEFRIDGGYNGSGIIESTDNYMLVVVMTNQLDLSATPLRARYSSSE 2576
            |                         .|..:|.....|:|...:    |:||..    .|:.:: 
Human   308 L-------------------------NYPENGWTPGEDSYREWI----QVDLGL----LRFVTA- 338

  Fly  2577 PTVCPPNIGDQATGSISIQSLLQVPGYHCTIKFVGTDSATLTFKVEEYLFQTAGGPAVVFRDDIT 2641
                   :|.|...|...:....|..|...:...|.|..|:....:..|||....|        |
Human   339 -------VGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNP--------T 388

  Fly  2642 NIPVKAMYANVTNSFVSVVTSAGSVTLLNSKNVKLRRFRATYRRHNCGGRLQAAEGVTIESPDLL 2706
            ::.|......:...||.:..:.....:    :::...:......:.|.|.|....|:..:|....
Human   389 DVVVAVFPKPLITRFVRIKPATWETGI----SMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449

  Fly  2707 TTLNDAYGEVECLWTLSNSNGYVLEGNVTLTDRCDREYIVIFSGQSEVGRICRGMAMNSTLLERP 2771
            :...|.....|.:..:::.:|:.|.   ........|::.|..|:.   :|.||:.:...     
Human   450 SNQGDRNWMPENIRLVTSRSGWALP---PAPHSYINEWLQIDLGEE---KIVRGIIIQGG----- 503

  Fly  2772 FSTILYHSESRLAQQSKFILQAWKSVSSGNAIRIDHRPSPPVTISSKNYLESKQRIW-------- 2828
                 .|.|:::..: ||.:....:.|....|..|.:........:.||...:.|.:        
Human   504 -----KHRENKVFMR-KFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFI 562

  Fly  2829 ----EFVTNDGLSLRLHFLERIFIVSSPNCSTDRLTVERYDQTTEEYIEVTSLCGRQAANDILVP 2889
                |..|:.||.||:..|         .|..:..|                 .|....|..||.
Human   563 RIYPERATHGGLGLRMELL---------GCEVEAPT-----------------AGPTTPNGNLVD 601

  Fly  2890 SARMRVIFQTNSNITGDGFSFQVIPSCDSVLLAGAEIQTLASPSWAAFRGRQFNCSY------TF 2948
            .....   |.|.: :|.|..||:  :..:.:||..:...:.|...:.|....|||.:      ||
Human   602 ECDDD---QANCH-SGTGDDFQL--TGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF 660

  Fly  2949 --YAHDNHQVVVSVRTRGRPWASYACSRSYFEAYRRGDGNGVGEES-------IGRL-------- 2996
              :.||||   |.::     |:.........:.:..||||.:..::       :.||        
Human   661 CHWEHDNH---VQLK-----WSVLTSKTGPIQDHTAGDGNFIYSQADENQKGKVARLVSPVVYSQ 717

  Fly  2997 ----CPEFEVKGNG------RVRLRYVSPLSR----WFEMQYQLIQCGGNYSTSFTLRPPQNEDS 3047
                |..|....:|      ||:|||..|...    |..:.:|    |.::           ::.
Human   718 NSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQ----GDHW-----------KEG 767

  Fly  3048 SVYAHNTLCEWRITAPPQHAVVIEFKYFDMESSR-NCG---FDSLTIYRGHVVSEEQRTGLLCGN 3108
            .|..|.:|..:::             .|:.|..: |.|   .|.::| ..|:..|:      |..
Human   768 RVLLHKSLKLYQV-------------IFEGEIGKGNLGGIAVDDISI-NNHISQED------CAK 812

  Fly  3109 VTNPETIIVNSNEALIVLTTDSSNSYRG 3136
            ..:    :...|..:.:..|.|:..|.|
Human   813 PAD----LDKKNPEIKIDETGSTPGYEG 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:394967
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001 37/113 (33%)
CUB 2327..2441 CDD:238001 30/127 (24%)
CUB 2688..2782 CDD:412131 17/93 (18%)
CUB 2810..2911 CDD:238001 20/112 (18%)
CUB 3029..3143 CDD:238001 18/112 (16%)
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
NRP1XP_006717584.1 CUB 27..140 CDD:238001 37/116 (32%)
CUB 147..264 CDD:238001 31/128 (24%)
FA58C 277..423 CDD:238014 31/205 (15%)
FA58C 435..582 CDD:238014 30/172 (17%)
MAM 650..811 CDD:459878 38/203 (19%)
DUF3481 846..924 CDD:403259
Blue background indicates that the domain is not in the aligned region.

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