DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42255 and TNFAIP6

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	NP_009046.2	Gene:	TNFAIP6 / 7130	HGNCID:	11898	Length:	277	Species:	Homo sapiens

Alignment Length:	283	Identity:	80/283 - (28%)
Similarity:	113/283 - (39%)	Gaps:	59/283 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   943 RASLVFHGSGGGRGMRLEYNFVPNQC---GGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHT 1004
            ||:.|:|........:|.|......|   ||.|            .|:.|    ....:||..|.
Human    33 RAAGVYHREARSGKYKLTYAEAKAVCEFEGGHL------------ATYKQ----LEAARKIGFHV 81

  Fly  1005 LGP---------TPSISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTINLHTNWPRLEIYSIQFDI 1060
            ...         .|.:       .||.  |...|..|.:..|  :.:|....|   :.|...
Human    82 CAAGWMAKGRVGYPIV-------KPGP--NCGFGKTGIIDYG--IRLNRSERW---DAYCYN--- 129

  Fly  1061 VQQDSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTD 1125
            .....|||.||......|||.:|..|.::|:|.|.:|..:|.||.|...:|.||::   .||..|
Human   130 PHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDD---PGCLAD 191

  Fly  1126 WLEIRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQM---GAGCGG 1187
            ::||.:...:....:|||||:|:|..|.|.|||:.|||.||.|:...||.:.:..|   .....|
Human   192 YVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQG 256

  Fly  1188 KLSSSMGTIHSPHLLAGNRGILA 1210
            |.:|:..|        ||:..||
Human   257 KNTSTTST--------GNKNFLA 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	6/19 (32%)
		CUB	1066..1179	CDD:238001	46/112 (41%)
		CUB	1185..1293	CDD:238001	8/26 (31%)
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
TNFAIP6	NP_009046.2	Link_domain_TSG_6_like	36..128	CDD:239592	23/121 (19%)
TNFAIP6	NP_009046.2	CUB	135..244	CDD:278839	46/111 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910