DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42255 and TLL2

DIOPT Version :9

Sequence 1:NP_729748.3 Gene:CG42255 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:NP_036597.1 Gene:TLL2 / 7093 HGNCID:11844 Length:1015 Species:Homo sapiens


Alignment Length:1234 Identity:239/1234 - (19%)
Similarity:389/1234 - (31%) Gaps:485/1234 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   926 RHIVKST----------DNLILLSHSNRASLVFHGSGGGRGMRL-------EYNFVPNQCG---G 970
            ||..|.|          ::.|:.|:.......:.|..||....:       ::..|.::.|   |
Human   185 RHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVG 249

  Fly   971 FLNE---PGR-RYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPSISIYDNSTSPGKLVNSYS--- 1028
            |.:|   |.| ::||.:|                               .:..||:..|...   
Human   250 FWHEHTRPDRDQHVTIIR-------------------------------ENIQPGQEYNFLKMEA 283

  Fly  1029 ---GSVGDVFDGDLLT----------INLHTNWPRLEIYSI-----------QFDIVQQ------ 1063
               .|:|:.:|.|.:.          :.|.|..||.:...:           |.||.|.      
Human   284 GEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKC 348

  Fly  1064 DSCGGTFTARFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLE 1128
            .:||.|.....|...:|.:|..|.....|.|.:....|.:|.|   |||..:.:.|..||.|::|
Human   349 PACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVL---NFTSMDLFKSRLCWYDYVE 410

  Fly  1129 IRNGDSESSPLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSM 1193
            :|:|....:||:||:||::||..:.|..:.|.::|:|..::..|||..:::   |.|||      
Human   411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE---ATCGG------ 466

  Fly  1194 GTIHSPHLLAGNRGILACDWQIIVAEGSRVSLQLRSNDNRICSGQLTLYDGPTTASNPIVIRCNG 1258
                                                                             
Human   467 ----------------------------------------------------------------- 466

  Fly  1259 TIAKPLQSTGNRVLVRYDVGHDAPDGTDFMLNYQTNCRVRLEGLQGAIETPNFPENYPPGQDCEW 1323
                             |:..||                      |.|::||:|::|.|.::|.|
Human   467 -----------------DMNKDA----------------------GQIQSPNYPDDYRPSKECVW 492

  Fly  1324 DIRAGGRKNHLQLIFSHLSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLL 1388
            .|.. ....|:.|.|....:|:..| |..||:.:.|...:::....|.|..:..|.:.:..|||.
Human   493 RITV-SEGFHVGLTFQAFEIERHDS-CAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLW 555

  Fly  1389 LRFKSDSSVELQGFRAEYKRIGCGEHLRESGGRFESPNAPFSVDMDCVWIITASEGNQIRLLLHE 1453
            ::|.||.|:...||.|.:.:                     .|| :|.|   ...|.        
Human   556 MKFVSDGSINKAGFAANFFK---------------------EVD-ECSW---PDHGG-------- 587

  Fly  1454 VYFEAPQIECRDAESSLSVSAPSGYNSSVVLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKY 1518
                     |...    .|:....|..      :|          .||.||        |..:| 
Human   588 ---------CEHR----CVNTLGSYKC------AC----------DPGYEL--------AADKK- 614

  Fly  1519 FKASFVQVPASCGGYISASSGVLTTPGFHNHQDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQF 1583
                  ....:|||:|:..:|.:|:||:..        .|.:|..|||.|.....|.|...||.|
Human   615 ------MCEVACGGFITKLNGTITSPGWPK--------EYPTNKNCVWQVVAPAQYRISLQFEVF 665

  Fly  1584 NLTDSGNCSVSFVEL-TKLEPDNKEIFLEKTCGEDSPMIRIVHGRKLRVRFKSQAGTWGRFIMYF 1647
            .|..:..|...|||: :.|.||.|  ...:.||.::|.:.......:||.|||..          
Human   666 ELEGNDVCKYDFVEVRSGLSPDAK--LHGRFCGSETPEVITSQSNNMRVEFKSDN---------- 718

  Fly  1648 ERQCGGRLSTGEGYLQSRLDEECSWLVTSPEGSKLSLIINQLECPKCNAVSQNCSEGLQLLNDDD 1712
                                      ..|..|.:.....::.||.|.|...|:     :.:|...
Human   719 --------------------------TVSKRGFRAHFFSDKDECAKDNGGCQH-----ECVNTFG 752

  Fly  1713 QVLLYQMCRDHPANLIVPANNVRILTHGIRLQAQFSTFENSCGGNITSASGSLSSPNYPDSYPAN 1777
            ..|.  .||          |...:..:|      ....|..|...|:|..|:|:|||:||.||:.
Human   753 SYLC--RCR----------NGYWLHENG------HDCKEAGCAHKISSVEGTLASPNWPDKYPSR 799

  Fly  1778 IECVWSIRTRPGNALEITFEAMDIVRSEHCNDDFLEIRSSVQ--GPLLALYCDKNLPETPLVVHS 1840
            .||.|:|.:..|:.:::||...:|.:.:.|..|.||:.....  .|:|..:|....|:..:...|
Human   800 RECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGS 864

  Fly  1841 ELWIKFRSRPGNTAGGFRFRWTYVHNNEINSGINGTIEPPPPLFVSNEDQPFTWRLFTDFKKVFV 1905
            .::::|.|.......||:    .||:.|....:...::                           
Human   865 SMFLRFYSDASVQRKGFQ----AVHSTECGGRLKAEVQ--------------------------- 898

  Fly  1906 LQFEEYISGLILFDGYDDNALAVNIPVSPWRFTSSSNVVYLKTVNDALTHFRLKWGVLDSNLVAS 1970
                                                                             
Human   899 ----------------------------------------------------------------- 898

  Fly  1971 NLSLTTGGCTKELTLSH--HGDIELSSPGYPHGYAPNLNCEWTIRSQFPSHHIYAHSIIVDLEDY 2033
                     |||| .||  .||         :.|.....|:|.|.:: ..:.:.......::|:.
Human   899 ---------TKEL-YSHAQFGD---------NNYPSEARCDWVIVAE-DGYGVELTFRTFEVEEE 943

  Fly  2034 PACSADYLSIQSSRD-----LIKWKNELHACKASQIAPVHGT-PYLRLQFRSDVSINGTGFRAK 2091
            ..|..||:......|     |.::      |.:..:..::.. ..|.::||:|.:||..||.|:
Human   944 ADCGYDYMEAYDGYDSSAPRLGRF------CGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHAR 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42255NP_729748.3 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 290..328 CDD:214542
EGF_CA 330..374 CDD:214542
EGF 427..455 CDD:278437
EGF_CA 462..496 CDD:238011
CUB 503..619 CDD:238001
CUB 624..738 CDD:238001
CUB 745..854 CDD:238001
CUB 857..963 CDD:238001 9/53 (17%)
CUB 1066..1179 CDD:238001 37/112 (33%)
CUB 1185..1293 CDD:238001 6/107 (6%)
CUB 1303..1406 CDD:238001 32/102 (31%)
CUB 1411..1523 CDD:238001 15/111 (14%)
CUB 1530..1648 CDD:238001 36/118 (31%)
CUB 1754..1862 CDD:238001 33/109 (30%)
CUB 1979..2091 CDD:238001 27/119 (23%)
CUB 2096..2193 CDD:294042
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:294042
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:294042
CUB 3499..3607 CDD:238001
TLL2NP_036597.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..130
ZnMc_BMP1_TLD 150..349 CDD:239808 34/194 (18%)
Astacin 157..350 CDD:279708 34/195 (17%)
CUB 351..460 CDD:278839 37/111 (33%)
CUB 464..573 CDD:278839 38/220 (17%)
FXa_inhibition 584..616 CDD:291342 11/83 (13%)
CUB 620..729 CDD:278839 38/154 (25%)
FXa_inhibition 736..771 CDD:291342 10/57 (18%)
CUB 776..885 CDD:278839 33/112 (29%)
CUB 889..1002 CDD:278839 28/231 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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