Protein Alignment Cubn2 and TLL1

DIOPT Version :10

• Sequence 1: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Sequence 2: NP_036596.3
• Gene: TLL1 / 7092
• HGNCID: 11843
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 979
• Identity: 228/979 - (23%)
• Similarity: 362/979 - (36%)
• Gaps: 289/979 - (29%)

  Fly   577 GRFCGSRLPMTNGSVITTQEQ--VFFWFRSDNQTQGKGFHVIWNSLPFSCGETINLTSTQTGVLR 639
            |.|.||:..|...::...::.  |.|..|||.::     ::::...|..|...:
Human   168 GNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEES-----YIVFTYRPCGCCSYV----------- 216

  Fly   640 SPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEASAGNCSQDSLIVY------------ 692
              |..|.. |:.                    ||:|.      ||.:..::|:
Human   217 --GRRGNG-PQA--------------------ISIGK------NCDKFGIVVHELGHVIGFWHEH 252

  Fly   693 ---DSDRQLLRACQSIQPPPVYS-------SSNSL--RLDFHTDAIRSDSSFQMHY--------- 736
               |.|..:....::|||...|:       ..|||  |.||  |:|       |||
Human   253 TRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDF--DSI-------MHYARNTFSRGM 308

  Fly   737 ---EVVPGH-----------------------------PGCGGVYTESRGRIS------GYMNFE 763
               .::|..                             |.||....||.|.:|      ||.::.
Human   309 FLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYT 373

  Fly   764 VCLYLIEQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSHEESELEPIISI 828
            .|::.:....|.::.|....:.|.:|..|.|..||:.||....:|||.|.||   :...|.:.|.
Human   374 HCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCG---DKLPEVLTST 435

  Fly   829 GNVILVRYEYALSGVRLSKSFDLTYTRVCTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDT 893
            .:.:.:  |:..|...:.|.|...|..:|.|....|.|.|.:||||..|.....|.:.:|  :..
Human   436 DSRMWI--EFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIT--VSE 496

  Fly   894 AVRMRITDLSLGTANNENDT-SYLDVYLSADQ------------KRHIVKSTDNLILLSHSNRAS 945
            :..:.:|..|.....::|.. .||:|.....:            |...::||.|.:.:      .
Human   497 SYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWM------K 555

  Fly   946 LVFHGSGGGRGMRLEYNFVPNQCGGFLNEPGRRYVTAVRGTFCQWFIDFPGRKKISIHTLGPTPS 1010
            .|..|:....|....:....::|.    :|.|                 .|.::..::|||.
Human   556 FVSDGTVNKAGFAANFFKEEDECA----KPDR-----------------GGCEQRCLNTLGS--- 596

  Fly  1011 ISIYDNSTSPGKLVNSYSGSVGDVFDGDLLTINLHTNWPRLEIYSIQFDIVQ-QDSCGGTFTARF 1074
               |..:..||                                |.:..|... :.:|||..|...
Human   597 ---YQCACEPG--------------------------------YELGPDRRSCEAACGGLLTKLN 626

  Fly  1075 GYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPL 1139
            |.|.:|.|||.|..::.|.|.:.||..:||.:....|.||   .:..|..|::||.:|.|..|.|
Human   627 GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELE---GNEVCKYDYVEIWSGLSSESKL 688

  Fly  1140 IGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSW-------QQMGAGCGGKLSSSMGT-- 1195
            .|::||.|:|..|.|..|.:.::||||:::.:|||...:       .:...||..:..::||:
Human   689 HGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYM 753

  Fly  1196 ------------------------IHSPHLLAGNRGILA-------------CDWQIIVAEGSRV 1223
                                    ||||      .|::.             |.|:|....|.|:
Human   754 CQCRNGFVLHDNKHDCKEAECEQKIHSP------SGLITSPNWPDKYPSRKECTWEISATPGHRI 812

  Fly  1224 SL---QLRSNDNRICS-GQLTLYDGPTTASNPIVIR-CNGTIAKPLQSTGNRVLVRYDVGHDAPD 1283
            .|   :.....::.|: ..|.::||.|..| ||:.| |...|..||.:|||::.||: |...:..
Human   813 KLAFSEFEIEQHQECAYDHLEVFDGETEKS-PILGRLCGNKIPDPLVATGNKMFVRF-VSDASVQ 875

  Fly  1284 GTDFMLNYQTNCRVRLEGLQGAIETP-------NFPENYPPGQ-DCEWDIRAGGRKNHLQLIFSH 1340
            ...|...:.|.|..||:    |...|       .|.:|..||| |||| :....|.:.|:|.|..
Human   876 RKGFQATHSTECGGRLK----AESKPRDLYSHAQFGDNNYPGQVDCEW-LLVSERGSRLELSFQT 935

  Fly  1341 LSVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAE 1405
            ..||: .:.|..|||.|.|.||...:.....|.:...|.|.::|:.:|:.|.:|.::..:||...
Human   936 FEVEE-EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIR 999

  Fly  1406 YKRI 1409
            ||.|
Human  1000 YKSI 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001	10/43 (23%)
		CUB	624..738	CDD:238001	27/149 (18%)
		CUB	745..854	CDD:238001	31/114 (27%)
		CUB	857..963	CDD:238001	25/118 (21%)
		CUB	1066..1179	CDD:238001	43/119 (36%)
		CUB	1185..1293	CDD:238001	34/151 (23%)
		CUB	1303..1406	CDD:238001	34/110 (31%)
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	39/232 (17%)
		CUB	349..458	CDD:395345	31/113 (27%)
		CUB	462..571	CDD:395345	25/116 (22%)
		FXa_inhibition	582..614	CDD:464251	10/86 (12%)
		CUB	618..727	CDD:395345	43/111 (39%)
		FXa_inhibition	734..769	CDD:464251	4/34 (12%)
		CUB	774..883	CDD:395345	31/116 (27%)
		CUB	887..1000	CDD:395345	37/118 (31%)