DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42255 and Tll1

DIOPT Version :9

Sequence 1:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster
Sequence 2:	NP_001099551.1	Gene:	Tll1 / 678743	RGDID:	1306120	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	191/807 - (23%)
Similarity:	320/807 - (39%)	Gaps:	208/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 EYNFVPNQCGGFLNEPGRRY-----VTAVRGTFCQ-WFIDFPGRKKISIHTLGPTPSISIYDNST 1018
            ||||:..: .|.:|..|.||     :...|.||.: .|:|          |:.|:..    ||..
  Rat   273 EYNFLKME-PGEVNSLGERYDFDSIMHYARNTFSRGMFLD----------TILPSRD----DNGI 322

  Fly  1019 SPGKLVNSYSGSVGD---VFDGDLLTINLHTNWPRLEIYSIQFDIVQQDSCGGTFTARFGYIKSP 1080
            .|         ::|.   :..||:.........|               :||.|.....|.:.||
  Rat   323 RP---------AIGQRTRLSKGDIAQARKLYRCP---------------ACGETLQESSGNLSSP 363

  Fly  1081 NWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESSPLIGRYCG 1145
            .:|..|.....|.|.:....|.:|.|   |||..:.|.|:.||.|::|:|:|....|||:||:||
  Rat   364 GFPNGYPSYTHCIWRVSVTPGEKIVL---NFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCG 425

  Fly  1146 NEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLLAGNRGILA 1210
            :::...:.|..:.:.::|:|..:...|||...::   |.|||::..:.|.|.||:.....|.:..
  Rat   426 DKVAGVLTSTDSRMWIEFRSSSNWVGKGFAAVYE---AICGGEIRKNEGQIQSPNYPDDYRPMKE 487

  Fly  1211 CDWQIIVAEGSRVSL-----QLRSNDNRICS-GQLTLYDGPTTASNPIVIR-CNGTIAKPLQSTG 1268
            |.|:|:|:||..|.|     ::..:|:  |: ..|.:.|| .:.::|::.| |.....:.::||.
  Rat   488 CVWKIMVSEGYHVGLTFQAFEIERHDS--CAYDHLEVRDG-NSENSPLIGRFCGYDKPEDIRSTS 549

  Fly  1269 NRVLVRYDVGHDAPDGT----DFMLN--------------------------YQTNCRVRLE--- 1300
            |.:.:::     ..|||    .|..|                          ||..|....|
  Rat   550 NTLWMKF-----VSDGTVNKAGFAANFFKEEDECAKADRGGCEQRCLNTLGSYQCACEPGYELGP 609

  Fly  1301 --------------GLQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHLSVEKFSSICL 1351
                          .|.|.|.||.:|:.|||.::|.|.:.|.. :..:.:.|....:|. :.:|.
  Rat   610 DRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVIAPS-QYRISVKFEFFELEG-NEVCK 672

  Fly  1352 NDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAEY---------- 1406
            .|||.:...|..::......|..|..|.||:..|.:.:.||||::|..:||:|.:
  Rat   673 YDYVEIWSGLSSESKLHGKFCGADVPEVITSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737

  Fly  1407 --------------------------------KRIGCGEHLRESGGRFESPNAP--FSVDMDCVW 1437
                                            |...|.:.:....|...|||.|  :....:|.|
  Rat   738 NGGCQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTW 802

  Fly  1438 IITASEGNQIRLLLHEVYFEAPQ--------IECRDAESSLSVSAPSGYNSSVVLFRSCHEETQT 1494
            .|:|..|::|:|..:|  ||..|        :|..|.::          ..|.:|.|.|..:. .
  Rat   803 AISAIPGHRIKLAFNE--FEVEQHQECAYDHLEIFDGQT----------EKSPILGRLCGSKI-P 854

  Fly  1495 QTFTSPGNELVIRFVSSSAPSRKYFKASFVQVPASCGGYISASSGVLTTPGFHNH-QDSKNVANY 1558
            ....:.|||:.|||:|.::..||.|:|:.   ...|||.:.|..   .....::| |...|  ||
  Rat   855 DPLMATGNEMFIRFISDASVQRKGFQATH---STECGGRLKAER---KPKDLYSHAQFGDN--NY 911

  Fly  1559 TSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIFLEKTCGEDSPM--- 1620
            ...::|.|.:....|..:...|:.|.:.:..:|...:||:.. ..::|.:.|.:.||...|.
  Rat   912 PGQLDCEWLLVSEQGSRLELSFQTFEVEEEADCGYDYVEVFD-GLNSKAVGLGRFCGSGPPEEIY 975

  Fly  1621 ----IRIVH--------GRKLRVRFKS 1635
                :.::|        .:...:|:||
  Rat   976 SIGDVALIHFHTDDTINKKGFYIRYKS 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	2/2 (100%)
		CUB	1066..1179	CDD:238001	37/112 (33%)
		CUB	1185..1293	CDD:238001	33/144 (23%)
		CUB	1303..1406	CDD:238001	32/102 (31%)
		CUB	1411..1523	CDD:238001	34/121 (28%)
		CUB	1530..1648	CDD:238001	26/122 (21%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
Tll1	NP_001099551.1	ZnMc_BMP1_TLD	148..347	CDD:239808	22/97 (23%)
		Astacin	155..348	CDD:279708	23/113 (20%)
		CUB	349..458	CDD:278839	37/111 (33%)
		CUB	462..571	CDD:278839	31/116 (27%)
		FXa_inhibition	582..614	CDD:291342	4/31 (13%)
		CUB	618..727	CDD:278839	33/110 (30%)
		FXa_inhibition	734..769	CDD:291342	0/34 (0%)
		CUB	774..883	CDD:278839	34/121 (28%)
		CUB	887..1000	CDD:278839	23/118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810