DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and thbs3b

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:XP_005170119.1 Gene:thbs3b / 571317 ZFINID:ZDB-GENE-060503-84 Length:952 Species:Danio rerio


Alignment Length:899 Identity:197/899 - (21%)
Similarity:295/899 - (32%) Gaps:333/899 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LRLMGESATVTINDVDMMTVLRRRQRIIADRQAARREPLKVDAVRDMFHDVELKMTRIQRRIFSA 118
            ||..|::.||.:.:..:..  .|.|.:|          |::..:|....::||.:.  .|.:.||
Zfish   101 LRSDGKAHTVNLQNPALAE--GRTQSLI----------LRIGGLRRSHINLELYVN--CRLVDSA 151

  Fly   119 RNSTKRSGLNQRI----LRRQLQRVERVKGILQT----LAGNLARNECLSNPCKNGGTCHDAYKG 175
            :......||....    :|...:...|::|::::    |.|:||.                  .|
Zfish   152 QGLPSFVGLPSEAESVDVRTGQKSYARIQGLVESVKLALGGSLAT------------------AG 198

  Fly   176 FQCECPAGWQGDSCEDDVNECFTLAGTDLDGCLNN------GQCI---NTPGSYR---------- 221
            ...:||  :||||.   :|....   :|::..|.:      ||.|   ...|..|          
Zfish   199 LLIDCP--FQGDSA---INNAVV---SDINAILGDHTKALIGQLIIFNQIMGELREDIREQTKEM 255

  Fly   222 ---------C-VCRNGFTGTHCRLRHNTCLFGGSRELCGEHGTCIQAANSAGYVC-ICDQGWTWA 275
                     | ||  ||.....|...|.|..|.|         |:::....||.| .|.:|.|  
Zfish   256 SLIRNTILECQVC--GFHEPQSRCLPNPCYTGVS---------CMESMMYPGYQCGPCPEGMT-- 307

  Fly   276 DANVTSASPSACVRDVDECEPRVNPCH--DECINLPGSFRCGACPTGYTG-------------DG 325
                  .:.:.| :|:|||  .|.||.  :.|:|....|.|.:||.|:||             ..
Zfish   308 ------GNGTHC-QDIDEC--TVQPCFSAELCVNTAKGFSCQSCPIGFTGPTLKGVGLEFAKRHK 363

  Fly   326 RFCRDIDECASEDNGGCSLQPRVTCTNTEGSHRCGRCPAGWTGD-------GRTCTASDSNSCNN 383
            :.|.|||||| |.:|.|  .|...|.||.||.:||:|.||:.|:       .|||.....:.|:.
Zfish   364 QHCVDIDECA-ELSGSC--VPNSVCINTVGSFKCGQCKAGFVGNQTVGCFARRTCETLGYSPCDV 425

  Fly   384 EGICHPLAKCEYVSDMVVCTCPLGSFGHGYGADGCSADSSRLPCDQHPCQNNGTCVQNGRGTTCI 448
            ...| .:.:...||    |.|.:|..|:| ...|..:|....|.:..||.:|.   ::.|...|.
Zfish   426 NSHC-VMGRNSDVS----CVCNVGWAGNG-NICGPDSDIDGYPDEPLPCMDND---KHCRADNCA 481

  Fly   449 CQPGYSGVVCNS----------SDACHPSPCLNG-----GTCRLLPDAKYQCVCPRGYTGTTCSH 498
            ..|       ||          .|.|......:|     ..|||:|:...|......| |..|.:
Zfish   482 NTP-------NSGQEDTDGDGIGDQCDEDADGDGIKNVEDNCRLVPNKDQQNSDTDSY-GDACDN 538

  Fly   499 QRFFCGVTIRGPSGQLHYPPNTADGDYQAD-----------------------ERCPFI---IRT 537
                |              ||..:|| |.|                       :.||.|   ::|
Zfish   539 ----C--------------PNVPNGD-QLDTDGNGKGDICDTDIDGDGIPNVLDNCPKIPNPMQT 584

  Fly   538 NRNMVLNLTFTQFQLEDSADCTADFLQLHDGNSLSSRLIGRFCGSRLPMTN------------GS 590
            :|                           ||:.     :|..|.| .|..|            |.
Zfish   585 DR---------------------------DGDG-----VGDACDS-CPEVNDPLQSDMDNDLVGD 616

  Fly   591 VITTQEQVFFWFRSDNQTQGKGFHVIWNSLPFSCGETIN---LTSTQTGV-------LRSPGYPG 645
            |..|.:.:          .|.|:    .....:|.|..|   |.|...|:       ..:.|.|.
Zfish   617 VCDTNKDI----------DGDGY----QDTRDNCPEVPNSSQLDSDNDGIGDECDDDDDNDGIPD 667

  Fly   646 QARPELDCRWQLTAPFGYRLLLRFYDISLGSSEASAGN-CSQDSLIVYDSDR--QLLRACQSIQP 707
            ...|         .|...||:.....|...::  ..|: |..|    :|:|:  .||.||.....
Zfish   668 ILPP---------GPDNCRLVPNPSQIDTDAN--GVGDVCETD----FDNDKVTDLLDACPESAE 717

  Fly   708 PPV--YSSSNSLRLDFHTDA------------------IRSDSSFQMHYEVVPGHPGCGGVYTES 752
            ..:  :.:..::.||...||                  :.||....:.|....|....|.::..:
Zfish   718 VTMTDFRAFQTVILDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTIHVNT 782

  Fly   753 R------GRISGYM---NFEVCLY--------------LIEQPRGTQVKLVIDR 783
            .      |.|.||.   :|.|.::              .:.|| |.|:|.|..|
Zfish   783 ATDDDYVGFIFGYQDSSSFYVVMWKQTEQTYWQNLPFKALAQP-GIQLKAVKSR 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063 18/90 (20%)
EGF_CA 156..190 CDD:238011 7/33 (21%)
EGF_CA 192..233 CDD:238011 13/69 (19%)
EGF_CA 290..328 CDD:214542 16/52 (31%)
EGF_CA 330..374 CDD:214542 23/50 (46%)
EGF 427..455 CDD:394967 6/27 (22%)
EGF_CA 462..496 CDD:238011 10/38 (26%)
CUB 503..619 CDD:238001 24/153 (16%)
CUB 624..738 CDD:238001 29/146 (20%)
CUB 745..854 CDD:238001 14/62 (23%)
CUB 857..963 CDD:238001
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
thbs3bXP_005170119.1 LamG <55..192 CDD:473984 21/104 (20%)
TSPcc 226..268 CDD:472419 6/41 (15%)
coiled coil 229..268 CDD:293922 6/38 (16%)
EGF_CA 315..350 CDD:238011 16/36 (44%)
EGF_CA 368..406 CDD:214542 21/40 (53%)
gliding_CglD 449..>705 CDD:468178 65/348 (19%)
TSP3 repeat_short 470..488 CDD:275365 6/27 (22%)
TSP_3 489..524 CDD:367074 7/34 (21%)
TSP3 repeat_long 489..524 CDD:275366 7/34 (21%)
TSP3 repeat_short 525..547 CDD:275366 9/41 (22%)
TSP_3 549..583 CDD:367074 4/33 (12%)
TSP3 repeat_long 549..583 CDD:275366 4/33 (12%)
TSP3 repeat_short 584..606 CDD:275366 9/54 (17%)
TSP3 repeat_long 607..644 CDD:275365 8/50 (16%)
TSP_3 686..719 CDD:367074 9/38 (24%)
TSP_C 738..935 CDD:461725 18/99 (18%)
Blue background indicates that the domain is not in the aligned region.

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