DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cubn2 and jag2a

DIOPT Version :10

Sequence 1:NP_729748.3 Gene:Cubn2 / 39334 FlyBaseID:FBgn0259140 Length:3613 Species:Drosophila melanogaster
Sequence 2:XP_694817.5 Gene:jag2a / 566455 ZFINID:ZDB-GENE-130530-549 Length:1230 Species:Danio rerio


Alignment Length:1049 Identity:240/1049 - (22%)
Similarity:353/1049 - (33%) Gaps:388/1049 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 NLARNECLSNPCKNGGTCHDAYKGFQCECPAGWQGDSCEDDVNEC----FTLAGTDLD------- 205
            :::::.|:||||.||||||:...||:|.||.||.|.:|..|.:||    .:..||.:|       
Zfish   333 HISKHACMSNPCANGGTCHELASGFECLCPPGWDGPTCAKDKDECESNPCSYGGTCIDLENGFEC 397

  Fly   206 ---------------------GCLNNGQCINTPGSYRCVCRNGFTGTHCRLRHNTCLFGGSRELC 249
                                 .|||...|.|..|.|.|.|..|:.|.:|.:..|:| :|    .|
Zfish   398 LCLPQWTGKTCQIDVNECTRRPCLNAYACKNLIGGYHCNCYPGWAGPNCNININSC-YG----QC 457

  Fly   250 GEHGTCIQAANSAGYVCICDQGWTWADANV----TSASP------------------------SA 286
            ...|||....:  ||||.|..|:......|    .::||                        :.
Zfish   458 QNGGTCQDGRH--GYVCQCQPGFMGRHCEVQQSRCASSPCQNGGRCRSLATGYECECLYGYTGNN 520

  Fly   287 CVRDVDECEPRVNPCHD--ECINLPGSFRCGACPTGYTGDGRFC---RD---------IDECAS- 336
            |...||.|.|  |||..  :|.:|.|.|.| ||...|  :|:.|   ||         ||.|.: 
Zfish   521 CEVQVDLCNP--NPCQKKAQCHSLQGDFYC-ACADEY--EGKTCSQLRDHCKTSTCHVIDSCTTA 580

  Fly   337 -------------------------EDNGG---CSLQPRV---------------------TCTN 352
                                     ..:||   |:.||..                     ||.:
Zfish   581 ITTNGTEKAVRYILSNVCGPHGRCISQSGGNFTCACQPGFSGTYCHENINDCESSPCHSGGTCID 645

  Fly   353 TEGSHRCGRCPAGWTGD------------------------------------GRTCTA----SD 377
            ...|.|| .||.|:.|.                                    |:||.:    .|
Zfish   646 DIDSFRC-VCPDGFDGQLCELEVNECSSDPCLNGGHCIDLLNDFYCRCTDNWKGKTCNSRENQCD 709

  Fly   378 SNSCNNEGICHPLAKCEYVSDMVVCTCPLGSFGHGYGADGCSA--DSSRLPCDQHPCQNNGTCVQ 440
            |::|.|.|.||..      .:...|.||     .|:|...|:.  :||   |:..||.|.|||:.
Zfish   710 SSTCANGGTCHDR------GESFRCLCP-----SGWGGSTCNTAMNSS---CESGPCLNGGTCIG 760

  Fly   441 NGRGTTCICQPGYSGVVC-NSSDACHPSPCLNGGTCRLLPDAK--YQCVCPRGYTGTTCSHQRFF 502
            :|....|||:.|:.|..| .:.|.|:|.||.|||.|   .|..  ::|.|..|:.|..|......
Zfish   761 SGSVFKCICKDGWEGPTCAQNVDDCNPHPCYNGGQC---VDGVNWFRCECAPGFAGPDCRINIDE 822

  Fly   503 C-------GVT----IRG-----PSGQLHYPPNTADGDYQADERCPFIIRTNRNMVLNLTFTQFQ 551
            |       |.|    |.|     |.|             :|..||...|...:            
Zfish   823 CQSSPCSYGATCVDEINGYRCLCPMG-------------RAGPRCQDFIGVGK------------ 862

  Fly   552 LEDSADCTADFLQLHDGNSLSSRLIGRF---CGSRLPMTNGSVITTQEQVFFWFRSDNQTQGKGF 613
                 .|....||:|.|        ||:   |.|...| ||::..|:                  
Zfish   863 -----ACDRSGLQVHHG--------GRWEDGCNSCQCM-NGNIKCTK------------------ 895

  Fly   614 HVIWNSLPFSCGETINLTSTQTGVLRSPGYP-GQ----------ARPELD----C--RWQLTAPF 661
                    .:||....|..:.:.|.:.|..| ||          .||..|    |  |.:| .|.
Zfish   896 --------VNCGHQSCLLQSDSEVAQRPLCPLGQECVEHHFLSCLRPPCDQLGMCSTRGRL-QPI 951

  Fly   662 GYRLLLR--FYDISLGSSEASAGNCSQDSLIVYDSDR--QLLRA---CQSIQPPPVYSSSNSLRL 719
            ..|.|..  :.|:          ||::.:| |:|||.  |...|   |..:...|:         
Zfish   952 NTRCLPNNGYLDV----------NCARVTL-VFDSDTVPQGTTAEGVCTELTYLPI--------- 996

  Fly   720 DFHTDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRISGYMNFEVCL-----YLIEQPRGTQ--V 777
               |..:..|.:..:..:..|                ||:...||.:     ..::.|....  |
Zfish   997 ---TRTLAKDHALFLLCDQSP----------------SGHNAVEVAMSYEQNNFVDGPAQIHDVV 1042

  Fly   778 KLVIDRVSLVQS----LSCHYLKIEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILVRYEY 838
            :.:||.:|...:    |:...::::..|.......|:..:|      .|..::.|..:|:..:.:
Zfish  1043 RSIIDVLSKPHNSTLLLAVREVRVDTQDPHPQVGYLIPLLC------VLFVVLWISCIIVCVWWF 1101

  Fly   839 ALSGVRLSKSFDLTYTRVCTGNFNTNSGIIS--TPNYPGPYFDDMTCTYNLTGPLDTAVRMRITD 901
            .    |..|:.....|::.....|....::|  ||:....  |.|....||..|||     |:.|
Zfish  1102 R----RRRKARQREDTQMEESINNQRGTLLSARTPHKDNT--DPMQENKNLLYPLD-----RVGD 1155

  Fly   902 LSLGTANNENDTSYLDVYLSADQKRHIVKSTDNLILLSHSNRASL-VFHGSGGGRGMRLEYNFVP 965
               |....|.:.       ..|::.:...:......|::|...:: |.|.|...:..|..|....
Zfish  1156 ---GAEREEEEE-------EGDEESNRGLALHKCSSLAYSKGDTVYVIHTSAQNQQHRTHYGGKD 1210

  Fly   966 NQCGGFLNE 974
            |:|...:||
Zfish  1211 NRCKNNVNE 1219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cubn2NP_729748.3 cubilin_NTD 38..141 CDD:412063
EGF_CA 156..190 CDD:238011 19/33 (58%)
EGF_CA 192..233 CDD:238011 17/72 (24%)
EGF_CA 290..328 CDD:214542 16/39 (41%)
EGF_CA 330..374 CDD:214542 20/138 (14%)
EGF 427..455 CDD:394967 12/27 (44%)
EGF_CA 462..496 CDD:238011 14/35 (40%)
CUB 503..619 CDD:238001 24/134 (18%)
CUB 624..738 CDD:238001 31/137 (23%)
CUB 745..854 CDD:238001 18/119 (15%)
CUB 857..963 CDD:238001 23/108 (21%)
CUB 1066..1179 CDD:238001
CUB 1185..1293 CDD:238001
CUB 1303..1406 CDD:238001
CUB 1411..1523 CDD:238001
CUB 1530..1648 CDD:238001
CUB 1754..1862 CDD:238001
CUB 1979..2091 CDD:238001
CUB 2210..2321 CDD:238001
CUB 2327..2441 CDD:238001
CUB 2688..2782 CDD:412131
CUB 2810..2911 CDD:238001
CUB 3029..3143 CDD:238001
CUB 3169..3249 CDD:412131
CUB 3499..3607 CDD:238001
jag2aXP_694817.5 MNNL 26..184 CDD:462222
DSL 171..228 CDD:128366
EGF_CA 295..332 CDD:238011
EGF_CA 340..370 CDD:238011 18/29 (62%)
EGF_CA 373..409 CDD:238011 6/35 (17%)
EGF_CA 411..446 CDD:238011 11/34 (32%)
EGF_CA 449..484 CDD:238011 13/41 (32%)
EGF_CA 490..522 CDD:238011 2/31 (6%)
EGF_CA 628..664 CDD:238011 9/36 (25%)
EGF_CA 667..701 CDD:238011 1/33 (3%)
EGF_CA 706..739 CDD:238011 12/43 (28%)
EGF_CA 781..816 CDD:238011 14/37 (38%)
EGF_CA 819..855 CDD:238011 9/48 (19%)
VWC_out 864..936 CDD:214565 23/106 (22%)
Blue background indicates that the domain is not in the aligned region.

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